Impact of HSD11B1 polymorphisms on BMI and components of the metabolic syndrome in patients receiving psychotropic treatments

Pharmacogenetics and Genomics
Lina QuteinehChin B Eap

Abstract

Metabolic syndrome (MetS) associated with psychiatric disorders and psychotropic treatments represents a major health issue. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is an enzyme that catalyzes tissue regeneration of active cortisol from cortisone. Elevated enzymatic activity of 11β-HSD1 may lead to the development of MetS. We investigated the association between seven HSD11B1 gene (encoding 11β-HSD1) polymorphisms and BMI and MetS components in a psychiatric sample treated with potential weight gain-inducing psychotropic drugs (n=478). The polymorphisms that survived Bonferroni correction were analyzed in two independent psychiatric samples (nR1=168, nR2=188) and in several large population-based samples (n1=5338; n2=123 865; n3>100 000). HSD11B1 rs846910-A, rs375319-A, and rs4844488-G allele carriers were found to be associated with lower BMI, waist circumference, and diastolic blood pressure compared with the reference genotype (Pcorrected<0.05). These associations were exclusively detected in women (n=257) with more than 3.1 kg/m, 7.5 cm, and 4.2 mmHg lower BMI, waist circumference, and diastolic blood pressure, respectively, in rs846910-A, rs375319-A, and rs4844488-G allele carriers compared with noncarriers (Pco...Continue Reading

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Citations

Mar 13, 2018·Current Opinion in Psychiatry·Clement C ZaiJames L Kennedy
May 27, 2020·Diabetes/metabolism Research and Reviews·Rosana Cristina MoriMaria Lúcia Correa-Giannella
Feb 27, 2016·Pharmacogenetics and Genomics·Núria Saigi-MorguiChin B Eap

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Methods Mentioned

BETA
transgenic
genotyping

Software Mentioned

Stata
hapMap Genome Browser
mgcv
CoLaus
haploview
R
GIANT

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