Impact of human immunodeficiency virus infection in pregnant women on variant-specific immunity to malaria

Clinical and Vaccine Immunology : CVI
Edson G DemboStephen J Rogerson

Abstract

Human immunodeficiency virus (HIV) increases susceptibility to Plasmodium falciparum infection, and this has most clearly been demonstrated in pregnant women. Variant surface antigens on the surfaces of erythrocytes infected with P. falciparum are major targets of protective immunity. We studied the impact of HIV infection on pregnant women's humoral immunity to variant surface antigens expressed by placental and pediatric isolates of P. falciparum. By flow cytometry, sera from HIV-infected women more frequently lacked antibodies to these antigens than sera from HIV-uninfected women. This difference was similar in magnitude for pediatric isolates (unadjusted odds ratio [OR] = 6.36; 95% confidence interval [CI] = 1.14, 35.32; P < 0.05) and placental isolates (unadjusted OR = 6.47; 95% CI = 0.75, 55.64; P < 0.10). We divided women into high and low responders on the basis of their antibody levels. After adjustment for CD4 count, maternal age, and gravidity, we found that HIV-infected women more frequently had low responses to both pediatric isolates (OR = 5.34; 95% CI = 1.23, 23.16; P = 0.025) and placental isolates (OR = 4.14; 95% CI = 1.71, 10.02; P = 0.002). The relative quantity of antibodies to both pediatric isolates (P = 0...Continue Reading

References

Nov 1, 1989·The American Journal of Tropical Medicine and Hygiene·F Wabwire-MangenT C Quinn
Mar 1, 1993·Annals of Internal Medicine·J W Buehler, J W Ward
Dec 3, 2005·The Journal of Infectious Diseases·Moses R KamyaDiane Havlir

❮ Previous
Next ❯

Citations

Aug 15, 2009·Interdisciplinary Perspectives on Infectious Diseases·Sarah Hochman, Kami Kim
Feb 22, 2012·Expert Review of Anti-infective Therapy·Raquel GonzálezAlfredo Mayor
Sep 22, 2009·Gynécologie, obstétrique & fertilité·I PoilaneL Carbillon
Jul 11, 2012·Expert Opinion on Pharmacotherapy·Azucena BardajíClara Menéndez
May 21, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne E FroschChandy C John
Jul 30, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Catherine A KossDeborah Cohan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Mario GiobbiaZeno Bisoffi
Emerging Infectious Diseases
Eric D'OrtenzioJacques Le Bras
© 2021 Meta ULC. All rights reserved