Impact of human immunodeficiency virus infection on Streptococcus pneumoniae colonization and seroepidemiology among Zambian women.

The Journal of Infectious Diseases
C J GillD H Hamer

Abstract

Nasopharyngeal colonization with Streptococcus pneumoniae precedes invasive pneumococcal disease. Human immunodeficiency virus (HIV) infection increases rates of invasive pneumococcal disease, and its effect on colonization is unknown. In a longitudinal cohort of Zambian mothers with or without HIV infection, HIV infection increased the risk of colonization (risk ratio [RR], 1.9; 95% confidence interval [CI], 1.3-2.8) and repeat colonization (RR, 2.4; 95% CI, 1.1-5.3) and reduced the time to new colonization (P = .01). Repeat colonization with homologous sero/factor types occurred only among HIV-positive mothers. Pediatric serotypes 6, 19, and 23 accounted for excess colonization among HIV-positive mothers. HIV infection significantly increases the risk of pneumococcal colonization. Increased rates of colonization by pediatric serotypes suggest a potential role for the 7-valent pneumococcal vaccine in HIV-infected adults.

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Citations

Jan 6, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Richard Malley
Jan 24, 2013·The Pediatric Infectious Disease Journal·Marta C NunesShabir A Madhi
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Sep 20, 2008·PLoS Pathogens·Ying-Jie LuRichard Malley
Feb 25, 2014·Current Infectious Disease Reports·James Brown, Marc Lipman
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May 26, 2016·Diagnostic Microbiology and Infectious Disease·Lee M HamptonLaura M Conklin
Feb 23, 2018·Frontiers in Zoology·Nicola HarrisonBarbara König

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