Impact of hyperthermia on pharmacokinetics of intraperitoneal mitomycin C in rats investigated by microdialysis

Journal of Surgical Oncology
Olaf SørensenKjersti Flatmark

Abstract

Patients with peritoneal surface malignancies are treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, commonly using mitomycin C (MMC). The purpose of this study was to investigate impact of hyperthermia on pharmacokinetics of intraperitoneal MMC. In 14 athymic nude male rats, microdialysis (MD) probes were implanted in jugular vein (V), hind leg muscle (M) and extraperitoneal space (XP). Probes were calibrated by retrodialysis. Intraperitonal chemotherapy perfusion (IPEC) was administered over 90 min with MMC 5 mg/kg and saline 0.9% 500 ml/kg at 35 and 41°C, defining the normothermic (NG) and hyperthermic groups (HG), respectively. MD and peritoneal perfusion fluid (PPF) samples were collected at 10 min intervals to determine MMC concentration. Time-concentration curves were virtually parallel between temperature groups, with equal peak concentrations (µM) of 0.3 (V), 0.7 (XP) and 0.3 (M). The following area under time-concentration curve (AUC) ratios were calculated: AUC PPF/AUC V were 69 in NG and 79 in HG (P = 0.54); AUC XP/AUC V were 2.7 in NG and 2.6 in HG (P = 0.90). IPEC provides high intraperitoneal MMC concentration and increased bioavailability in extraperitoneal tissue, combined with lo...Continue Reading

References

Jan 27, 1998·Cancer Chemotherapy and Pharmacology·P JacquetP H Sugarbaker
Dec 8, 2000·Advanced Drug Delivery Reviews·E C de LangeD D Breimer
Feb 27, 2001·Journal of Surgical Oncology·S R PestieauP H Sugarbaker
Jul 6, 2002·Critical Reviews in Oncology/hematology·Bert HildebrandtHanno Riess
Oct 22, 2003·Surgical Oncology Clinics of North America·S van RuthF A Zoetmulder
Oct 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Renzo ColomboMichele Pavone-Macaluso
Mar 30, 2004·Cancer Chemotherapy and Pharmacology·O GlehenP H Sugarbaker
Nov 3, 2006·Pharmacology & Therapeutics·Ronald J Tallarida
Apr 20, 2007·Journal of Clinical Pharmacology·Chandra S ChaurasiaHelen Yeo
Apr 27, 2007·Pharmaceutical Research·Chandra S ChaurasiaHelen Yeo
Jul 6, 2007·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Hong ZhengJin-Hong Hu
Feb 21, 2008·Journal of Clinical Pharmacology·Stephan SchmidtHartmut Derendorf
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Hunter R Moyer, Keith A Delman
Sep 16, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rolf D Issels

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