PMID: 15228097Jul 2, 2004Paper

Impact of hypoglycemia and diabetes on CNS: correlation of mitochondrial oxidative stress with DNA damage

Molecular and Cellular Biochemistry
Puneet SinghG Kaur

Abstract

Oxidative stress plays an important role in tissue damage caused by hypoglycemia and diabetes, which may be the result of deterioration in glucose homeostasis caused by these metabolic disorders. The present study examined the effects of insulin-induced hypoglycemia and streptozotocin induced diabetes on mitochondrial lipid peroxidation and antioxidant enzymes from different brain regions, namely, cerebral hemispheres, cerebellum, brain stem and diencephalon. In situ localization of DNA single strand breaks (SSBs) were also studied by DNA polymerase-I mediated biotin dATP labeled nick translation method after inducing hypoglycemia and diabetes. Significant decrease in mitochondrial catalase, manganese superoxide-dismutase (Mn-SOD) and reduced glutathione (GSH) content and increase in the lipid peroxidation (LPx) and glutathione peroxidase (GPx) activity was observed under these metabolic stress conditions with more pronounced effects in hypoglycemic group. We conclude that during severe energy deprivation following hypoglycemia and diabetes, mitochondrial free radicals scavenger system is down regulated, which leads to reactive oxygen species (ROS) generation. High levels of ROS in turn activate the processes leading to DNA dam...Continue Reading

Citations

Jun 4, 2010·Antioxidants & Redox Signaling·Xavier FioramontiVanessa H Routh
Jan 17, 2014·Journal of Neuroendocrinology·V F H JensenJ Lykkesfeldt
Mar 5, 2014·Metabolic Brain Disease·Leticia Amador-AlvaradoLourdes Massieu
Jun 25, 2016·Canadian Journal of Physiology and Pharmacology·T R AnjuC S Paulose
Mar 10, 2017·Expert Review of Clinical Pharmacology·Sherifa A Hamed
Sep 13, 2018·Drug and Chemical Toxicology·Yuri Karen SinzatoDébora Cristina Damasceno
Jun 19, 2007·Biochemistry. Biokhimii︠a︡·N K IsaevD B Zorov
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Kyoung Ah KangJin Won Hyun
Oct 25, 2011·Sensors·Vanessa H Routh
Aug 1, 2013·Human & Experimental Toxicology·C PoissonY Gueguen
Sep 26, 2013·International Journal of Endocrinology·Amanda Nunes SantiagoRoberto Barbosa Bazotte
May 17, 2014·Metabolic Brain Disease·Aarti NagayachIshan Patro
Mar 24, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Guilhian LeipnitzMoacir Wajner
Feb 3, 2018·International Journal of Radiation Biology·Naglaa Elshahat Mohamed, Saleh E Ashour
Apr 4, 2007·The Journal of Clinical Investigation·Sang Won SuhRaymond A Swanson
Feb 11, 2010·Journal of Diabetes Science and Technology·Jean-Claude LacheradeJean-Charles Preiser
Apr 14, 2012·Journal of Aging Research·Ana I DuarteCatarina R Oliveira
Mar 15, 2018·Journal of Clinical Medicine·Melanie Li, Swetlana Sirko
Jan 29, 2019·Endocrine Reviews·Sarah StanleyElizabeth R Seaquist
Oct 28, 2010·Antioxidants & Redox Signaling·Corinne LeloupLuc Pénicaud
Jan 1, 2008·Clinical Medicine. Oncology·Syed Imam RabbaniSalma Khanam
Sep 24, 2011·Oxidative Medicine and Cellular Longevity·Saleh A Bakheet, Sabry M Attia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.