Impact of hyponatremia on nerve conduction and muscle strength

European Journal of Clinical Investigation
F VandergheynstGuy Decaux

Abstract

Hyponatremia is associated with unstable gait and propensity to falls. The potential contribution of peripheral nervous system dysfunction induced by hyponatremia has not yet been addressed by prospective studies. In the first part of this prospective study, we performed two tests evaluating muscle strength (grip test and quadriceps isometric contraction test) together with a timed up and go (TUG) test in 11 patients with chronic mild-to-moderate hyponatremia before and after the normalization of natremia. In the second part, we measured nerve conduction velocities and F-wave latencies in nine patients with profound hyponatremia (< 125 mmol/L) before and after the normalization of natremia. No significant change in muscle strength was observed when natremia was corrected from 127·7 ± 2·5 to 136·1 ± 1·8 mmol/L, contrary to a significant improvement in TUG from 14·9 ± 5·1 to 12·5 ± 4·7 s (P = 0·006). Nerve conduction velocities and F-wave latencies showed significant improvement in most of the studied nerves when natremia was corrected from 121·9 ± 2·4 to 135·5 ± 3·4 mmol/L (e.g. mean increase of 14·3% for motor nerve conduction and mean decrease of 21·6% for F-wave latency of left peroneal nerve). Whereas chronic mild-to-moderat...Continue Reading

Associated Clinical Trials

Oct 19, 2020·Helbert Rondon

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Citations

Jan 12, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J C AyusA L Negri
Aug 29, 2018·European Journal of Clinical Investigation·Julie RefardtWiebke Fenske
Oct 13, 2018·Acta Clinica Belgica·G Decaux
Jun 25, 2019·Current Opinion in Nephrology and Hypertension·Ewout J Hoorn, Goce Spasovski
May 14, 2020·Expert Review of Endocrinology & Metabolism·Guy Decaux, Fabrice Gankam Kengne
Jan 13, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A L AdamsJ J Sim
Mar 28, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Api ChewcharatKianoush B Kashani
Feb 20, 2021·International Urology and Nephrology·Cihan HeybeliPinar Soysal

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