Impact of hypothyroidism on the development of non-alcoholic fatty liver disease: A 4-year retrospective cohort study

Clinical and Molecular Hepatology
Kil Woo LeeYong Kyun Cho

Abstract

Hypothyroidism is reported to contribute to the development of nonalcoholic fatty liver disease (NAFLD). We compared the risk of the development of NAFLD among three groups with different thyroid hormonal statuses (control, subclinical hypothyroidism, and overt hypothyroidism) in a 4-year retrospective cohort of Korean subjects. Apparently healthy Korean subjects without NAFLD and aged 20-65 years were recruited (n=18,544) at health checkups performed in 2008. Annual health checkups were applied to the cohort for 4 consecutive years until December 2012. Based on their initial serum-free thyroxine (fT4) and thyroid-stimulating hormone (TSH) levels, they were classified into control, subclinical hypothyroidism (TSH >4.2 mIU/L, normal fT4), and overt hypothyroidism (TSH >4.2 mIU/L, fT4 <0.97 ng/dL) groups. NAFLD was diagnosed on the basis of ultrasonography findings. NAFLD developed in 2,348 of the 18,544 subjects, representing an overall incidence of 12.7%: 12.8%, 11.0%, 12.7% in the control, subclinical hypothyroidism, and overt hypothyroidism groups, respectively. The incidence of NAFLD did not differ significantly with the baseline thyroid hormonal status, even after multivariate adjustment (subclinical hypothyroidism group: h...Continue Reading

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Citations

Jun 24, 2017·Journal of Hepatology·Jian-Gao FanVincent Wai-Sun Wong
Aug 8, 2018·Thyroid : Official Journal of the American Thyroid Association·Alessandro MantovaniGiovanni Targher
Oct 28, 2018·Hormone Molecular Biology and Clinical Investigation·Simonetta LugariAmedeo Lonardo
Jun 20, 2019·International Journal of Molecular Sciences·Amedeo LonardoGiovanni Targher
Apr 21, 2018·Digestive Diseases and Sciences·Alessandro Mantovani, Giorgio Grani
Aug 23, 2020·International Journal of Molecular Sciences·Daniela Maria TanaseMariana Floria
Oct 22, 2020·Journal of Clinical and Translational Hepatology·Tomislav KizivatMartina Smolic
Dec 15, 2020·World Journal of Gastroenterology : WJG·Ze-Yu WuBing Chang
Apr 2, 2021·Frontiers in Cell and Developmental Biology·Shizheng QiuYang Hu
May 5, 2021·Journal of Health, Population, and Nutrition·Guanqun Chao, Liying Chen
Dec 3, 2021·Chinese Medical Journal·Rafael S RiosMing-Hua Zheng

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