Impact of hypovitaminosis D on clinical, hormonal and insulin sensitivity parameters in normal body mass index polycystic ovary syndrome women

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
Mohd Ashraf GanieZaffar Amin Shah

Abstract

Earlier data on the relationship of 25 hydroxyvitamins (25OHD) levels with various components of polycystic ovary syndrome (PCOS) has been conflicting. We studied 122 normal body mass index (BMI) women with PCOS (cases) and 46 age and BMI-matched healthy women (controls) and assessed the impact of serum 25OHD levels on clinical, biochemical and insulin sensitivity parameters in these lean Indian women with PCOS. The mean age and BMI of the cases and controls were comparable. Mean serum 25OHD levels respectively were 10.1 ± 9.9 and 7.9 ± 6.8 ng/ml with 87.7% and 91.1% vitamin D (VD) deficient. No significant correlation was noted between 25OHD levels and clinical, biochemical and insulin sensitivity parameters except with the total testosterone levels (p = 0.007). Also, no significant difference in these parameters was observed once the PCOS women were stratified into various subgroups based on the serum 25OHD levels. We conclude that VD deficiency being common in normal BMI Indian women with or without PCOS does not seem to alter the metabolic phenotype in these women.

References

Nov 1, 1961·The Journal of Clinical Endocrinology and Metabolism·D FERRIMAN, J D GALLWEY
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Jul 23, 2005·Clinical Chemistry·Dimitrios PanidisEvanthia Diamanti-Kandarakis
Dec 21, 2006·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·S HahnO E Janssen
Nov 9, 2007·Postgraduate Medical Journal·A H ZargarZ A Shah
Feb 14, 2009·Archives of Gynecology and Obstetrics·Recep YildizhanMansur Kamaci
Feb 24, 2009·Fertility and Sterility·Touraj MahmoudiZahra Ezabadi
Jul 4, 2009·Taiwanese Journal of Obstetrics & Gynecology·Batool RashidiFarid Zayerii
Jul 25, 2009·European Journal of Endocrinology·E WehrB Obermayer-Pietsch
Mar 3, 2010·Annals of Internal Medicine·Anastassios G PittasEthan M Balk
Nov 27, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S DevarajI Jialal
Jan 26, 2011·Nature Reviews. Endocrinology·Mark O GoodarziRicardo Azziz
May 10, 2011·Metabolism: Clinical and Experimental·Hang Wun Raymond LiClement K M Ho
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Dec 14, 2011·Journal of Clinical Research in Pediatric Endocrinology·Dilek ErdönmezAlev Keser
Jan 21, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Giovanna MuscogiuriAndrea Giaccari
Jan 26, 2012·European Journal of Endocrinology·Elisabeth Lerchbaum, Barbara Obermayer-Pietsch
Apr 17, 2012·Complementary Therapies in Clinical Practice·Raziah dehghani FirouzabadiSomayeh MohammadTaheri
May 12, 2012·Clinical Endocrinology·Rebecca L ThomsonJonathan D Buckley
May 19, 2012·Endocrine Reviews·Clifford J RosenChristopher S Kovacs
Nov 20, 2012·Diabetes & Metabolic Syndrome·Surajeet K PatraAnju Jain

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Citations

Jan 20, 2017·Reviews in Endocrine & Metabolic Disorders·Giovanna MuscogiuriFrancesco Orio
Jun 7, 2017·Hormone Molecular Biology and Clinical Investigation·Beng Kwang NgNor Azlin Mohamed Ismail
Nov 22, 2018·Cancer Cell International·Chunjiao Song, Huan Chen
Dec 12, 2019·The Indian Journal of Medical Research·Mohammad Ashraf GanieAafia Rashid

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