Impact of impaired coronary flow reserve and insulin resistance on myocardial energy metabolism in patients with syndrome X

The American Journal of Cardiology
H E BøtkerT T Nielsen

Abstract

To evaluate the role of a decreased coronary flow reserve in the genesis of angina pectoris in patients with syndrome X, we studied myocardial hemodynamics and metabolism at rest, during pace stress, and in the recovery period after pacing in 18 consecutive patients with syndrome X and in 10 control subjects. By means of positron emission tomography or the intracoronary flow-wire method, patients were subclassified as having microvascular angina (MA, n = 8) when coronary flow reserve was reduced (<2.5) or no microvascular angina (non-MA, n = 10) when coronary flow reserve was preserved (> or =2.5). At rest, coronary sinus blood flow was increased in MA patients. During pace stress, coronary sinus blood flow increased by 39 +/- 6% in MA patients versus 67 +/- 12% in non-MA patients and 69 +/- 7% in controls (p <0.05). Patients with non-MA revealed fasting hyperinsulinemia, increased arterial concentration of free fatty acids, and a similar tendency for beta-hydroxybutyrate. Oxygen extraction and carbon dioxide release did not differ between groups. Net myocardial lactate release was not observed in any patient during pace stress and myocardial energy metabolism was preserved in all patients with syndrome X. During pacing, myocar...Continue Reading

References

Jun 1, 1991·Journal of the American College of Cardiology·P G CamiciM Marzilli
Jun 1, 1991·Journal of the American College of Cardiology·A Maseri
Mar 15, 1990·Journal of the American College of Cardiology·B E Strauer
Jun 1, 1988·The American Journal of Cardiology·R O Cannon, S E Epstein
Jun 1, 1986·British Heart Journal·S C Webb, P A Poole-Wilson
Mar 1, 1970·Scandinavian Journal of Clinical and Laboratory Investigation·K E Wildenhoff
Jul 1, 1984·Clinics in Endocrinology and Metabolism·P A Poole-Wilson
Feb 1, 1980·Circulation·E W GertzJ D Bristow
Jul 17, 1993·Lancet·H E BøtkerJ P Bagger
Dec 1, 1993·British Heart Journal·D R HoldrightP Collins

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Citations

Apr 20, 2014·Basic Research in Cardiology·Leif OstergaardHans Erik Bøtker
Oct 23, 1997·The Journal of Clinical Investigation·H E BotkerT T Nielsen
Oct 31, 2000·International Journal of Cardiology·J W ChenM S Chang
Jan 9, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Giovanni StortoAlberto Cuocolo
Mar 2, 2013·International Journal of Evidence-based Healthcare·David P Di Fiore, John F Beltrame
Mar 3, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Satake OsamichiTakekoshi Noboru
Apr 26, 2006·European Journal of Clinical Investigation·S GrafM Zehetgruber
Nov 15, 2000·The American Journal of Cardiology·J P BaggerT T Nielsen
Mar 26, 1999·Journal of the American College of Cardiology·H E BøtkerF Andreasen

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