Abstract
This study sought to assess the impact of implantable cardioverter-defibrillators (ICDs) on waitlist mortality in patients listed for heart transplantation (HT). The impact of ICDs on preventing sudden cardiac death in patients awaiting HT has not been studied in large multicenter cohorts. Furthermore, whether ICDs benefit patients with a left ventricular assist device (LVAD) is unknown. Adults (age ≥18 years) listed for first-time HT in the United States between January 1, 1999, and September 30, 2014, were retrospectively identified from the United Network for Organ Sharing registry. The primary predictor variable was the presence of an ICD at the time of listing. Primary outcome variable was all-cause waitlist mortality. Data on 32,599 patients (mean age 53 ± 12 years, 77% male, 70% Caucasian) were analyzed. During median follow-up of 154 days, 3,638 patients (11%) died on the waitlist (9% in ICD group vs. 15% in no-ICD group; p < 0.0001), whereas 63% underwent HT. Having an ICD at listing was associated with an adjusted 13% relative reduction in mortality (hazard ratio: 0.87; 95% confidence interval: 0.80 to 0.94). In the subgroup of patients with LVAD (n = 9,478), having an ICD was associated with an adjusted 19% relative ...Continue Reading
References
Dec 1, 1994·Journal of the American College of Cardiology·M C OzH R Levin
Jan 17, 2002·The New England Journal of Medicine·E A RoseUNKNOWN Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group
Mar 22, 2002·The New England Journal of Medicine·Arthur J MossUNKNOWN Multicenter Automatic Defibrillator Implantation Trial II Investigators
Jul 30, 2002·Cardiology·Panayotis FasseasBharat K Kantharia
Feb 5, 2004·The American Journal of Cardiology·Chiara PedoneAngelo Branzi
Aug 7, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Sacha P SalzbergMarko I Turina
Jan 22, 2005·The New England Journal of Medicine·Gust H BardyUNKNOWN Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators
Nov 15, 2006·Clinical Transplantation·Francesco GrigioniAngelo Branzi
Apr 18, 2007·The American Journal of Cardiology·Maninder BediSrinivas Murali
Sep 1, 2007·The New England Journal of Medicine·Leslie W MillerUNKNOWN HeartMate II Clinical Investigators
Sep 25, 2007·Journal of the American College of Cardiology·Katherine Lietz, Leslie W Miller
Oct 4, 2007·JAMA : the Journal of the American Medical Association·Adrian F HernandezEric D Peterson
Dec 22, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael R Da RosaJean-Francois Légaré
Jun 30, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mads AndersenFinn Gustafsson
Nov 19, 2009·The New England Journal of Medicine·Mark S SlaughterUNKNOWN HeartMate II Investigators
Feb 25, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Daniel J CantillonBruce L Wilkoff
Feb 15, 2011·Revista española de cardiología·Teresa Bastante ValienteCarlos Sáenz de la Calzada
Jun 18, 2011·Pacing and Clinical Electrophysiology : PACE·Daniel B SimsUlrich P Jorde
Jan 17, 2012·Circulation. Heart Failure·Tajinder P SinghDionne A Graham
Feb 4, 2012·Journal of Cardiac Failure·Marwan M RefaatMarc A Simon
Aug 18, 2012·Pacing and Clinical Electrophysiology : PACE·Jennifer YuhasRachel Lampert
Sep 15, 2012·Journal of the American College of Cardiology·Cynthia M TracyPaul D Varosy
May 7, 2013·Journal of the American College of Cardiology·Arthur R GaranNir Uriel
Jul 23, 2013·Circulation. Arrhythmia and Electrophysiology·Alan D EnriquezSean P Pinney
Jul 23, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kairav VakilSelcuk Adabag
Oct 13, 2014·International Journal of Cardiology·Kairav VakilMonica Colvin-Adams
May 6, 2015·Pacing and Clinical Electrophysiology : PACE·William LeeChristopher S Hayward
Citations
Nov 1, 2017·Circulation·Sana M Al-KhatibRichard L Page
Nov 1, 2017·Circulation·Sana M Al-KhatibRichard L Page
Feb 20, 2018·Current Heart Failure Reports·Jad Al DanafAmin Yehya
Sep 12, 2019·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Aswini KumarJeffrey Kluger
Aug 19, 2020·Pacing and Clinical Electrophysiology : PACE·Alejandra GutierrezSelcuk Adabag
May 21, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Dennis Lawin, Christoph Stellbrink
Jul 10, 2019·Journal of the American Heart Association·Paulino A AlvarezRandall C Starling
May 16, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ahmed ElkaryoniAlan P Wimmer
Sep 5, 2020·Southern Medical Journal·Katherine PicelSelcuk Adabag
Feb 3, 2021·Artificial Organs·Jaimin R TrivediRakesh Gopinathannair