PMID: 16508398Mar 2, 2006Paper

Impact of in vivo preconditioning by isoflurane on adenosine triphosphate-sensitive potassium channels in the rat heart: lasting modulation of nucleotide sensitivity during early memory period

Anesthesiology
Anna StadnickaZeljko J Bosnjak

Abstract

The early memory of anesthetic-induced preconditioning (APC) is a period when myocardial protection continues even after removal of the anesthetic. Because adenosine triphosphate-sensitive potassium (KATP) channels are important mediators of APC, the authors investigated the hypothesis that the memory involves channel priming by isoflurane via a long-term modulation of the sensitivity to intracellular adenosine nucleotides. Ventricular cardiomyocytes were obtained from the rat hearts after 30 min in vivo APC with 1.4% isoflurane and from control non-APC rat hearts. Whole cell and excised inside-out patch clamp techniques were used to study the sarcolemmal KATP channel. Membrane expression of KATP channel proteins, the pore-forming inward rectifier Kir6.2, and the regulatory sulfonylurea receptor SUR2A were assessed in APC and non-APC hearts by Western blotting. Activation of whole cell KATP current by isoflurane was enhanced after in vivo APC. At the single-channel level, this was paralleled by a 12-fold decrease in adenosine 5'-triphosphate sensitivity and a 3-fold decrease in adenosine 5'-diphosphate sensitivity, without changing the probability of channel opening or single-channel conductance. The membrane expression of Kir6...Continue Reading

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Citations

Apr 27, 2007·Journal of Anesthesia·Anna StadnickaZeljko J Bosnjak
Aug 30, 2012·Medical Gas Research·Nicole R Van AllenJohn H Zhang
Dec 24, 2014·Anesthesiology·Jessica M OlsonZeljko J Bosnjak
Oct 4, 2014·Frontiers in Physiology·Bhawana AgarwalAmadou K S Camara
Jan 15, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Jasna MarinovicMartin Bienengraeber

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