Impact of increased utilization of neoadjuvant chemotherapy on survival in patients with advanced ovarian cancer: experience from a comprehensive cancer center

Journal of Gynecologic Oncology
Yong Jae LeeYoung Tae Kim

Abstract

The choice between primary debulking surgery (PDS) and neoadjuvant chemotherapy (NAC) in advanced ovarian cancer remains controversial. We evaluated NAC use in our center before and after results from a randomized trial were published, with the aim to determine the impact of changes in the neoadjuvant strategy on survival in advanced-stage ovarian cancer. We retrospectively investigated the clinical course of 435 patients with ovarian, tubal, or peritoneal carcinoma (International Federation of Gynecology and Obstetrics [FIGO] stage III or IV). According to the period of treatment, we stratified patients into a control group (n=216; diagnosed between 2006 and 2010; 83.8% underwent PDS) and a study group (n=219; diagnosed between 2011 and 2014; 48.9% received NAC followed by interval debulking surgery [IDS]). There were no between-group differences in age, body mass index, histology findings, or tumor grade. Compared to patients in the control group, those in the study group were more likely to receive NAC followed by IDS as first-line treatment (48.9% vs. 16.2%; p<0.001), cytoreductive surgery to no-residual disease (21.5% vs. 10.2%; p<0.001), or radical surgery (57.5% vs. 35.6%; p<0.001). However, there was no between-group di...Continue Reading

References

Jan 6, 2006·Obstetrics and Gynecology·Giovanni D AlettiWilliam A Cliby
Jan 6, 2006·The New England Journal of Medicine·Deborah K ArmstrongUNKNOWN Gynecologic Oncology Group
Sep 20, 2008·American Journal of Obstetrics and Gynecology·Anna FagottiGiovanni Scambia
Sep 8, 2010·The New England Journal of Medicine·Ignace VergoteUNKNOWN NCIC Clinical Trials Group
Oct 12, 2010·Gynecologic Oncology·Giovanni D AlettiWilliam A Cliby
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne F Schott, Daniel F Hayes
Nov 10, 2012·Journal of the National Comprehensive Cancer Network : JNCCN·Robert J MorganUNKNOWN National Comprehensive Cancer Network
Oct 30, 2013·Journal of Gynecologic Oncology·Myong Cheol LimSang-Yoon Park
Jul 22, 2014·Journal of Gynecologic Oncology·Jung-Yun LeeYoung-Joo Won
Mar 22, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anna FagottiGiovanni Scambia

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Citations

Nov 7, 2019·The Cochrane Database of Systematic Reviews·Sarah L ColeridgeJo Morrison
Feb 6, 2021·The Cochrane Database of Systematic Reviews·Sarah L ColeridgeJo Morrison
Aug 24, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shufeng DuanCaixia Chen

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Methods Mentioned

BETA
bilateral oophorectomy
pancreatectomy

Software Mentioned

SPSS

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