Impact of inflammation-mediated myocardial fibrosis on the risk of recurrence after successful ablation of atrial fibrillation - the FIBRO-RISK study: Protocol for a non-randomized clinical trial

Medicine
Szilamer KorodiImre Benedek

Abstract

Interventional ablation has been demonstrated to represent an effective therapy in patients with atrial fibrillation (AF), leading to restoration and maintenance of sinus rhythm in the majority of cases. However, recurrence of AF is encountered in 35% to 40% of cases, and the causes for this frequent complication have not been elucidated so far. Here we present the study protocol of the FIBRO-RISK trial, a prospective, single-center, cohort study which aims to investigate the impact of inflammatory-mediated myocardial fibrosis on the risk of recurrence after successful catheter ablation of atrial fibrillation. The level of systemic inflammation in the pre-ablation and immediate post-ablation period will be assessed on the basis of serum levels of inflammatory biomarkers (hsCRP, matrix metalloproteases, interleukin-6), while the level of cardiac fibrosis will be determined based on cardiac magnetic resonance imaging associated with complex post-processing techniques for mapping myocardial fibrosis at the level of left atrium and left ventricle. At the same time, the amount of epicardial fat will serve as an indirect marker of localized inflammation and will be determined at different levels in the heart (surrounding left atrium,...Continue Reading

References

May 15, 1997·The New England Journal of Medicine·S R OmmenM S Stanton
Nov 19, 2003·Circulation·Ronnier J AvilesMina K Chung
Nov 16, 2004·The American Journal of Cardiology·Jeffrey L AndersonUNKNOWN Intermountain Heart Collaborative Study group
Nov 21, 2007·Journal of the American College of Cardiology·Tim T IssacNasser M Lakkis
Oct 18, 2008·Journal of the American College of Cardiology·Christopher J McGannNassir F Marrouche
Nov 18, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Konstantinos P LetsasThomas Arentz
Dec 10, 2009·Circulation. Arrhythmia and Electrophysiology·Riccardo CappatoElia Biganzoli
Jan 21, 2011·Physiological Reviews·Ulrich SchottenAndreas Goette
May 29, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mehmet AkkayaNassir F Marrouche
Dec 24, 2013·Circulation. Arrhythmia and Electrophysiology·Christopher McGannNassir F Marrouche
Feb 19, 2014·European Heart Journal·Stanley NattelA John Camm
May 13, 2014·JACC. Cardiovascular Imaging·Felipe BisbalLluís Mont
Jan 17, 2015·Circulation. Arrhythmia and Electrophysiology·James L HarrisonMark D O'Neill

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Citations

May 16, 2020·Frontiers in Cardiovascular Medicine·Xiaoxu Zhou, Samuel C Dudley
May 19, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Marinela Couselo-SeijasSonia Eiras

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