Impact of inhaled nitric oxide stewardship programme in a neonatal intensive care unit.

Journal of Paediatrics and Child Health
Joshua AhearnTejasvi Chaudhari

Abstract

Inhaled nitric oxide (iNO) is the most common, although expensive, therapy for persistent pulmonary hypertension of the newborn and hypoxaemic respiratory failure. With significant variation in iNO delivery practices amongst clinicians, this study aimed to assess the effectiveness of a stewardship programme in increasing clinician compliance with revised, standardised protocols and to measure the impact of compliance on iNO therapy use. Initiation and weaning protocols for iNO were introduced to the neonatal intensive care unit at The Centenary Hospital on 01 March 2016. A 2-year stewardship programme was utilised to assess protocol compliance and the resulting iNO usage impacts were measured. A combined retrospective and prospective study from 1 March 2014 to 28 February 2018 was conducted to compare the patterns of iNO utilisation between the pre- and post-stewardship cohorts. The pre-stewardship cohort incorporated 18 neonates, receiving 19 iNO treatment episodes, and 18 neonates, receiving 21 iNO treatment episodes, in the post-stewardship cohort. No significant difference in patient demographics was determined. Compliance with the protocols improved from 61% in year 1 to 88% in year 2 of the stewardship programme. Signific...Continue Reading

References

Jul 28, 2006·The New England Journal of Medicine·John P KinsellaSteven H Abman
Mar 20, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robin H Steinhorn
Sep 21, 2011·Pediatrics·Lisa M AskieUNKNOWN Meta-analysis of Preterm Patients on Inhaled Nitric Oxide Collaboration
May 21, 2013·Jornal de pediatria·Joaquim E B Cabral, Jaques Belik
Apr 1, 2012·Journal of Clinical Neonatology·Martin Keszler
Mar 15, 2015·Paediatric Respiratory Reviews·Perraju BendapudiAnne Greenough
Sep 4, 2015·Nitric Oxide : Biology and Chemistry·Pavan BhatrajuJohn D Lang
Jan 1, 2015·Maternal Health, Neonatology and Perinatology·Vinay SharmaSatyan Lakshminrusimha
Aug 3, 2016·Seminars in Perinatology·Gregory M SokolKrisa P Van Meurs
Sep 8, 2016·Hospital Pediatrics·Amir ElmekkawiRobert P Jankov
Dec 21, 2016·Pharmacotherapy·Alexander H FlanneryJeremy D Flynn
Aug 10, 2017·Children·Bobby Mathew, Satyan Lakshminrusimha
Mar 30, 2018·Quality Management in Health Care·Tanya Di GenovaPeter C Laussen

❮ Previous
Next ❯

Citations

Jun 21, 2020·Pediatric Research·Dimitrios AngelisLina Chalak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.