Impact of Initial Ventilatory Strategy in Hematological Patients With Acute Respiratory Failure: A Systematic Review and Meta-Analysis

Critical Care Medicine
Laura Amado-RodríguezGuillermo M Albaiceta

Abstract

Acute respiratory failure in hematological patients is related to a high mortality. Noninvasive mechanical ventilation may benefit a subset of these patients, but the overall effect on mortality and the risks derived from its failure are unclear. Our objective was to review the impact of initial ventilatory strategy on mortality and the risks related to noninvasive mechanical ventilation failure in this group of patients. Data sources, including PubMed and conference proceedings, were searched from the year 2000 to January 2015. We selected studies reporting mortality and the need for mechanical ventilation in hematological patients with acute respiratory failure. Two trained reviewers independently conducted study selection, abstracted data, and assessed the risk of bias. Discrepancies between reviewers were resolved through discussion and consensus. The outcomes explored were all-cause mortality after mechanical ventilation and incidence of noninvasive mechanical ventilation failure. A random-effects model was used in all the analysis. Thirteen studies, involving 2,380 patients, were included. Use of noninvasive mechanical ventilation was related to a better outcome than initial intubation (risk ratio, 0.74; 95% CI, 0.65-0.84...Continue Reading

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Citations

Sep 17, 2016·Critical Care Medicine·Gulsah KaraorenAntonio M Esquinas
Sep 17, 2016·Critical Care Medicine·Laura Amado-Rodriguez, Guillermo M Albaiceta
Nov 5, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Maryline ChomtonGuillaume Emeriaud
Sep 28, 2017·Thorax·Jorge Blázquez-PrietoGuillermo M Albaiceta
Apr 29, 2018·Annals of Hematology·M G KiehlUNKNOWN Consensus of the German Society of Hematology and Medical Oncology (DGHO), Austrian Society of Hematology and Oncology (OeGH
Sep 8, 2019·Critical Care : the Official Journal of the Critical Care Forum·Guillaume DumasElie Azoulay
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Oct 13, 2020·Medizinische Klinik, Intensivmedizin und Notfallmedizin·P WohlfarthUNKNOWN Arbeitsgruppe für Hämato-Onkologische Intensivmedizin der Österreichischen Gesellschaft für Allgemeine und Internistische In

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