Impact of injected dose and acquisition time on a normal database by use of 3D-SSP in SPECT images: quantitative simulation studies

Radiological Physics and Technology
Hideo OnishiNoboru Katsuta

Abstract

The present study aimed to validate the accuracy of normal databases (NDBs) with respect to variable injected doses and acquisition times by use of three-dimensional stereotactic surface projections (3D-SSP) in N-isopropyl-p-[123I]-iodoamphetamine (I-123-IMP) brain perfusion images. We constructed NDBs based on brain SPECT images obtained from 29 healthy volunteers. Each NDB was rebuilt under simulated unique conditions by use of dynamic acquisition datasets and comprised injected doses (222, 167, and 111 MBq) and acquisition times (30, 20, and 15 min). We selected seven of 29 datasets derived from the volunteers to simulate patients' data (PD). The simulated PD were designed to include regions of hypoperfusion. The study comprised protocol A (same conditions for PD and NDB) and protocol B (mismatched conditions for PD and NDB). We used 3D-SSP to compare with the Z score and detection error. The average Z scores were decreased significantly in protocol A [PD (High)-NDB (High) vs. PD (Low)-NDB (Low); PD (30 m)-NDB (30 m) vs. PD (15 m)-NDB (15 m) and PD (20 m)-NDB (20 m)].The average Z scores of PD (High) and PD (Medium) with NDB (High) did not differ significantly in protocol B, whereas all others were decreased significantly. T...Continue Reading

References

Jul 13, 2001·Annals of Nuclear Medicine·H Matsuda
Feb 21, 2003·Annals of Nuclear Medicine·Kazunari Ishii
Jan 27, 2012·Annals of Nuclear Medicine·Kazunari IshiiTakamichi Murakami

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Citations

Dec 12, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Shoko OtaKyoko Suzuki

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