PMID: 9429213Jan 1, 1997Paper

Impact of interferon-alpha therapy on the development of hepatocellular carcinoma in patients with liver cirrhosis: results of an international survey

Journal of Viral Hepatitis
F BoninoM R Brunetto

Abstract

Clinico-epidemiological data show that the most severe forms of hepatitis C virus (HCV) associated liver disease occur in patients with multifactorial liver damage. We found that the prevalence of hepatitis B virus (HBV) markers in anti-HCV positive patients with cirrhosis complicated by hepatocellular carcinoma (HCC) is higher than in cirrhotics with comparable age and disease history, but without HCC. HBV can persist in integrated forms in HBsAg negative, anti-HBc positive individuals and we may speculate that in such patients concurrent liver pathogens, as HCV, could cause HCC more easily than in patients without previous exposure to HBV. Analysing the relations between age at HCC diagnosis and the different risk factors in consecutive HCC patients we found that patients with single hepatitis virus infections (HBsAg and/or anti-HCV positive) were of an older median age than patients with multiple hepatitis virus infections. We also studied patients with compensated cirrhosis and hepatitis virus infections. untreated or treated with interferon-alpha. The independent effect of treatment was analysed by matching groups with regard to all the other significant HCC risk factors. The overall relative HCC risk was three times highe...Continue Reading

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Citations

Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·E Tabor
Aug 9, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Man-Fung YuenChing-Lung Lai
May 24, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G Carosi, M Rizzetto
Apr 14, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·A LegrandG Feldmann
Dec 19, 2003·Journal of Clinical Pharmacology·UNKNOWN Global Burden Of Hepatitis C Working Group
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Daniel Lavanchy
Oct 7, 2006·Current Opinion in Gastroenterology·G A Macdonald

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