Impact of interlukin-6 on central obesity measures in women with polycystic ovarian syndrome.

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
Eman M AlissaNisma M Al Mansouri

Abstract

Our aim was to investigate the relationship between plasma interleukin-6 (IL-6) levels with different measures of central obesity among Saudi women with and without polycystic ovarian syndrome (PCOS). One hundred and sixty-four Saudi females, between 22 and 38 years of age, with and without PCOS were enrolled in this case-control study. Physical examination and laboratory tests were completed for every subject. 2/3 of the study population were obese. Fasting serum insulin, plasma IL-6 levels and insulin resistance show significant increase among POCS than the controls (p<.05). Based on linear regression analysis, C-reactive protein (hs-CRP) was the only independent predictor of plasma IL-6 levels, accounting for 4% of the variability in plasma IL-6 (β = 0.217, p=.005, 95% CI: 0.049-0.275). Coexistence of metabolic and inflammatory factors in PCOS females is accompanied by central obesity which overpowers the effect of insulin resistance, contributing to higher plasma levels of IL-6 and CRP.Impact statementWhat is already known on this subject? Polycystic ovary syndrome (PCOS) is a cluster of many cardiovascular risk factors, but is also known as an inflammatory condition. Insulin resistance and abdominal obesity are classic com...Continue Reading

References

Jul 31, 1998·The American Journal of Medicine·W H Frishman
Jun 9, 2001·The Journal of Clinical Endocrinology and Metabolism·C C KellyN Sattar
Jul 24, 2001·JAMA : the Journal of the American Medical Association·A D PradhanP M Ridker
Aug 18, 2001·Hormone Research·S ToprakA Corakçi
Feb 15, 2002·Human Fertility : Journal of the British Fertility Society·Sarah WildPaul McKeigue
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Edmund A BermudezPaul M Ridker
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Anne R CappolaLinda P Fried
May 27, 2003·Diabetes Care·Zachary T Bloomgarden
Jun 12, 2003·Obstetrics and Gynecology·Giovanni AmatoAlfredo Izzo
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Apr 15, 2004·European Journal of Endocrinology·Matthias MöhligChristof Schöfl
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Ricardo AzzizBulent O Yildiz
Aug 18, 2005·The Journal of Clinical Endocrinology and Metabolism·Jardena J PuderBeat Müller
Jan 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Joan C LoAlan S Go
Jul 15, 2006·Metabolism: Clinical and Experimental·Alexandros N VgontzasRichard S Legro
Aug 19, 2007·Trends in Endocrinology and Metabolism : TEM·Héctor F Escobar-Morreale, José L San Millán
Apr 21, 2009·Metabolism: Clinical and Experimental·Frank GonzálezJohn P Kirwan
Mar 5, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Akmal El-MaznyAhmed El-Mazny
Apr 30, 2010·Arquivos brasileiros de cardiologia·Eduardo Caldas CostaGeorge Dantas Azevedo
Oct 29, 2010·Fertility and Sterility·Ricardo AzzizMark O Goodarzi
Dec 21, 2010·Fertility and Sterility·Héctor F Escobar-MorrealeFrank González
Dec 24, 2011·Fertility and Sterility·Antoni J Duleba, Anuja Dokras
Jun 26, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Antoaneta Trifonova Gateva, Zdravko Asenov Kamenov
Oct 16, 2012·Endocrine Reviews·Evanthia Diamanti-Kandarakis, Andrea Dunaif
Nov 2, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S S LimL J Moran
Jan 30, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Poli Mara SpritzerDebora M Morsch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.