Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Clare EckoldTANDEM consortium

Abstract

People with diabetes have an increased risk of developing active tuberculosis (TB) and are more likely to have poor TB-treatment outcomes, which may impact on control of TB as the prevalence of diabetes is increasing worldwide. Blood transcriptomes are altered in patients with active TB relative to healthy individuals. The effects of diabetes and intermediate hyperglycemia (IH) on this transcriptomic signature were investigated to enhance understanding of immunological susceptibility in diabetes-TB comorbidity. Whole blood samples were collected from active TB patients with diabetes (glycated hemoglobin [HbA1c] ≥6.5%) or IH (HbA1c = 5.7% to <6.5%), TB-only patients, and healthy controls in 4 countries: South Africa, Romania, Indonesia, and Peru. Differential blood gene expression was determined by RNA-seq (n = 249). Diabetes increased the magnitude of gene expression change in the host transcriptome in TB, notably showing an increase in genes associated with innate inflammatory and decrease in adaptive immune responses. Strikingly, patients with IH and TB exhibited blood transcriptomes much more similar to patients with diabetes-TB than to patients with only TB. Both diabetes-TB and IH-TB patients had a decreased type I interfe...Continue Reading

References

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Citations

Aug 7, 2021·International Journal of General Medicine·Shengsheng LiuShenjie Tang

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Methods Mentioned

BETA
RNA-seq
PCA

Software Mentioned

DESeq2
TANDEM
package
R
GeneOverlap

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