Impact of interpatient variability on organ dose estimates according to MIRD schema: Uncertainty and variance-based sensitivity analysis

Medical Physics
Alexandra ZverevaKatia Parodi

Abstract

Variance-based sensitivity analysis (SA) is described and applied to the radiation dosimetry model proposed by the Committee on Medical Internal Radiation Dose (MIRD) for the organ-level absorbed dose calculations in nuclear medicine. The uncertainties in the dose coefficients thus calculated are also evaluated. A Monte Carlo approach was used to compute first-order and total-effect SA indices, which rank the input factors according to their influence on the uncertainty in the output organ doses. These methods were applied to the radiopharmaceutical (S)-4-(3-18 F-fluoropropyl)-L-glutamic acid (18 F-FSPG) as an example. Since 18 F-FSPG has 11 notable source regions, a 22-dimensional model was considered here, where 11 input factors are the time-integrated activity coefficients (TIACs) in the source regions and 11 input factors correspond to the sets of the specific absorbed fractions (SAFs) employed in the dose calculation. The SA was restricted to the foregoing 22 input factors. The distributions of the input factors were built based on TIACs of five individuals to whom the radiopharmaceutical 18 F-FSPG was administered and six anatomical models, representing two reference, two overweight, and two slim individuals. The self-abs...Continue Reading

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Citations

Sep 21, 2019·International Journal of Radiation Biology·Petra SeiboldMaria Blettner
Aug 23, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kenneth J NicholsAndrew Van Tosh
Apr 18, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lukas M CarterAdam Leon Kesner

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Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
Alexandra ZverevaKatia Parodi
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Vladimir SpielmannChristoph Hoeschen
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