Impact of intracoronary injection of CD133+ bone marrow stem cells on coronary atherosclerotic progression in patients with STEMI: a COMPARE-AMI IVUS substudy

Coronary Artery Disease
Fuyu QiuSamer Mansour

Abstract

Adverse effects of intracoronary injection of stem cells on in-stent restenosis and atherosclerotic progression remain unclear. We sought to evaluate the adverse effects of intracoronary injection of CD133 cells on in-stent restenosis and atherosclerotic progression in the infarct-related and contralateral arteries using serial intravascular ultrasound (IVUS) analysis. Baseline and 4-month follow-up IVUS images were obtained from 17 patients treated with intracoronary stem cell injection and 20 placebo patients after primary percutaneous coronary intervention in the COMPARE-AMI trial. In the infarct-related artery, the stented segment, 5 mm proximal and distal reference segments, and proximal and distal nonstented segments were analyzed every 1 mm; the entire segment of a contralateral artery was also analyzed every 1 mm. In the infarct-related artery analysis, the median percentage of in-stent neointimal hyperplasia (12.1 vs. 7.6%, P=0.95), the reduction in the minimum lumen area (MLA; -1.6 vs. -1.5 mm(2), P=0.97), and the MLA at follow-up (4.3 vs. 5.3 mm(2), P=0.21) were found to be similar between the stem cell and placebo groups. Changes in proximal and distal nonstented segment lumen areas and plaque burden were also simil...Continue Reading

References

Oct 22, 2002·American Journal of Physiology. Cell Physiology·Arup ChakrabortyC Wayne Smith
Oct 19, 2004·Journal of the American College of Cardiology·Volker SchächingerAndreas M Zeiher
Sep 23, 2006·The New England Journal of Medicine·Volker SchächingerUNKNOWN REPAIR-AMI Investigators
Apr 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroyuki OkuraJunichi Yoshikawa
Mar 29, 2014·Circulation. Cardiovascular Interventions·Renate de JongHenricus J Duckers
Jul 8, 2014·Journal of Molecular and Cellular Cardiology·Noemi PavoMariann Gyöngyösi

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