Impact of iron overload in myelodysplastic syndromes

Blood Reviews
Pierre Fenaux, Christian Rose

Abstract

Anaemia is prevalent in patients with myelodysplastic syndromes (MDS), and most patients with MDS receive regular red blood cell transfusions, which can lead to iron overload. Some patients may already have iron overload before transfusions begin, as a result of ineffective erythropoiesis. Iron overload has been linked to hepatic, cardiac, and endocrine dysfunction, although its exact contribution to cardiac failure and other complications is difficult to determine due to the advanced age of MDS patients and the prevalence of comorbidities. In addition, in patients with lower-risk MDS, a high serum ferritin level has been associated with an increased risk of leukaemic evolution independent of other prognostic factors, possibly related in part to the accumulation of free iron radicals. Finally, iron overload has been associated with poorer outcome after allogeneic stem cell transplantation and possibly with increased risk of infection. Thus, iron overload may negatively influence survival in patients with MDS, especially those with lower-risk disease. Iron chelation therapy may be beneficial in these patients.

References

Feb 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E Karp, W G Merz
Aug 1, 1971·The American Journal of Medicine·L M Buja, W C Roberts
Feb 5, 1981·The New England Journal of Medicine·A I SchaferH F Bunn
May 1, 1993·The Journal of Clinical Investigation·J R BoelaertY J Schneider
Feb 17, 1997·FEBS Letters·W BreuerZ I Cabantchik
Jan 1, 1997·Free Radical Biology & Medicine·M DürkenA R Zander
May 31, 2001·British Journal of Haematology·L SahlstedtT Ruutu
Nov 13, 2001·British Journal of Haematology·J B Porter
Mar 29, 2002·The Hematology Journal : the Official Journal of the European Haematology Association·A CortelezziM D Cappellini
Sep 28, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Luca MalcovatiMario Cazzola
Mar 30, 2007·European Journal of Haematology·Masaaki TakatokuUNKNOWN Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes
Oct 18, 2007·Blood·Sophie ParkUNKNOWN GFM group (Groupe Francophone des Myélodysplasies)
Jan 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy R AsmisUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Apr 9, 2008·Current Opinion in Hematology·Elizabeta Nemeth
Sep 3, 2008·Bone Marrow Transplantation·V PullarkatS J Forman
Sep 4, 2008·American Journal of Hematology·John M Bennett, UNKNOWN MDS Foundation's Working Group on Transfusional Iron Overload
Sep 10, 2008·Blood·Elisa RumiMario Lazzarino
Oct 23, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Uwe PlatzbeckerH Joachim Deeg
Nov 4, 2008·Current Opinion in Infectious Diseases·Ashraf S IbrahimJohn Edwards

❮ Previous
Next ❯

Citations

Sep 3, 2011·PloS One·Valeria SantiniMaria Domenica Cappellini
Jun 27, 2012·Haematologica·Andréa TomaCatherine Cordonnier
Sep 4, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P FenauxUNKNOWN ESMO Guidelines Working Group
Jun 23, 2015·Surgical Neurology International·Russell L Blaylock
Mar 25, 2014·Lancet·Lionel AdèsPierre Fenaux
Apr 6, 2012·La Revue de médecine interne·C Rose
May 20, 2015·Clinical and Experimental Medicine·Ana Cristina GonçalvesAna Bela Sarmento-Ribeiro
Apr 12, 2013·Blood·Pierre Fenaux, Lionel Adès
Mar 10, 2017·Expert Review of Hematology·Maximilian Stahl, Amer M Zeidan
Apr 5, 2018·Leukemia & Lymphoma·André Barbosa RibeiroAna Bela Sarmento-Ribeiro
Jul 31, 2020·The Kaohsiung Journal of Medical Sciences·Xue-Qiong WuTing Yang
Nov 15, 2011·Expert Review of Hematology·Katja SockelUwe Platzbecker
Nov 23, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P FenauxUNKNOWN ESMO Guidelines Committee
Aug 10, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Eirini ChrysochouEvangelos Bakeas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.