Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease.

Journal of the American Heart Association
Joseph YangPeter Ganz

Abstract

Background Chronic kidney disease (CKD) confers increased cardiovascular risk, not fully explained by traditional factors. Proteins regulate biological processes and inform the risk of diseases. Thus, in 938 patients with stable coronary heart disease from the Heart and Soul cohort, we quantified 1054 plasma proteins using modified aptamers (SOMAscan) to: (1) discern how reduced glomerular filtration influences the circulating proteome, (2) learn of the importance of kidney function to the prognostic information contained in recently identified protein cardiovascular risk biomarkers, and (3) identify novel and even unique cardiovascular risk biomarkers among individuals with CKD. Methods and Results Plasma protein levels were correlated to estimated glomerular filtration rate (eGFR) using Spearman-rank correlation coefficients. Cox proportional hazard models were used to estimate the association between individual protein levels and the risk of the cardiovascular outcome (first among myocardial infarction, stroke, heart failure hospitalization, or mortality). Seven hundred and nine (67.3%) plasma proteins correlated with eGFR at P<0.05 (ρ 0.06-0.74); 218 (20.7%) proteins correlated with eGFR moderately or strongly (ρ 0.2-0.74)....Continue Reading

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Citations

Jul 23, 2020·Journal of the American Heart Association·Fatimah K KhalafDavid J Kennedy
Jul 25, 2021·International Journal of Molecular Sciences·Joanna Tracz, Magdalena Luczak
Nov 18, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Nicholas M PajewskiJeff D Williamson

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Software Mentioned

Ingenuity Pathway Analysis ( IPA )
SomaLogic

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