Impact of laparoscopic sleeve gastrectomy on fibrosis stage in patients with child-A NASH-related cirrhosis.

Surgical Endoscopy
Mohamed Abdalla SalmanAhmed Abdallah Salman

Abstract

Bariatric surgery can improve non-alcoholic fatty liver disease (NAFLD). Yet data on the effect on fibrosis are insufficient and controversial. This work endeavored to evaluate the safety of laparoscopic sleeve gastrectomy (LSG) in cases that have compensated non-alcoholic steatohepatitis (NASH)-related cirrhosis and its impact on fibrosis stage. The current prospective work involved 132 cases with Child-A NASH-related cirrhosis suffering from morbid obesity scheduled for LSG. They were subjected to preoperative assessment, wedge biopsy, and ultrasound-guided true-cut liver biopsy after 30 months. Patients were included if proved to have F4 fibrosis initially. The liver condition was assessed based on the NALFD Activity Score (NAS). The primary outcome measure was the impact of LSG on fibrosis stage and its relation to weight loss. The analysis included only 71 patients who completed the 30-month follow-up period. By the end of the follow-up interval, there was a substantial weight loss with a reasonable resolution of comorbidities. The median NAS decreased significantly from 6 (1-8) to 3 (0-6) after surgery. Fibrosis score regressed to F2 in 19 patients (26.8%) and F3 in 29 (40.8%). Patients with improved scores had a signific...Continue Reading

References

Dec 4, 2003·Journal of the American College of Surgeons·Alessandra Puggioni, Linda L Wong
Oct 4, 2005·Obesity Surgery·Charalabos StratopoulosEvagelos Hadjiyannakis
Mar 21, 2006·Obesity Surgery·Soraya Rodrigues de AlmeidaAlexandre Lages Savassi Rocha
Mar 23, 2007·Journal of Gastroenterology and Hepatology·Carlos K FuruyaFlair J Carrilho
Feb 26, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Mark C TakataAndrew M Posselt
Nov 7, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rajasekhara R MummadiGagan K Sood
Dec 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisa FabbriniSamuel Klein
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elizabeth M BruntUNKNOWN NASH Clinical Research Network (CRN)
Apr 5, 2011·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Elie K ChouillardUNKNOWN Intercontinental Society of Natural Orifice, Endoscopic, and Laparoscopic Surgery (i-NOELS)
May 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Annalisa BerzigottiUNKNOWN Portal Hypertension Collaborative Group
Jul 26, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jeffrey D Mosko, Geoffrey C Nguyen
Nov 24, 2011·Obesity Surgery·Myriam MorettoCláudio C Mottin
Dec 4, 2012·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Hideharu ShimizuStacy A Brethauer
Feb 20, 2013·Journal of Hepatology·Martin BlachierFrançoise Roudot-Thoraval
Mar 12, 2013·Obesity Surgery·Elaine Cristina VianaNazaré Souza Bissoli
Dec 21, 2013·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Lionel RebiboJean-Marc Regimbeau
Dec 30, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Andrew A TaitanoMichel M Murr
Apr 29, 2015·Gastroenterology·Guillaume LassaillyPhilippe Mathurin
May 20, 2015·Obesity Surgery·Ahmad JanKamal K Mahawar
May 25, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·P Praveen RajChinnusamy Palanivelu
Jun 17, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Dvir FroylichPhilip Schauer
Oct 6, 2015·Metabolism: Clinical and Experimental·Nancy E Aguilar-OlivosNahum Méndez-Sánchez
Jun 13, 2017·The New England Journal of Medicine·UNKNOWN GBD 2015 Obesity CollaboratorsChristopher J L Murray
Oct 28, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Archana RastogiShiv Sarin
Nov 12, 2017·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Harshit GargSamagra Agarwal
Aug 2, 2018·World Journal of Gastroenterology : WJG·George Boon-Bee GohArthur J McCullough

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Citations

Dec 20, 2020·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Lokesh AgarwalSandeep Aggarwal
Feb 18, 2021·Obesity Surgery·Saleem AhmedUNKNOWN Global Bariatric Research Collaborative
Apr 13, 2021·Obesity Science & Practice·Ali Y FakhreddineCatherine T Frenette
Sep 4, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Giovanna FerraioliJonathan R Dillman
Sep 23, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vinay SundaramRobert J Wong
Apr 27, 2021·Obesity Surgery·Aashir KaulRajni Yadav
Aug 28, 2021·Nutrients·Maria CerretoFrancesca Romana Ponziani

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