Impact of left atrial volume in prediction of outcome after cardiac resynchronization therapy

International Journal of Cardiology
Xuedong ShenDennis J Esterbrooks

Abstract

Left atrial volume index (LAVI) as a predictor of mortality has not been well investigated in patients with cardiac resynchronization therapy (CRT). The purpose of this study is to evaluate the impact of LAVI in predicting mortality in CRT patients. We studied 100 consecutive patients who received CRT (male 73, age 69.9 ± 9.6 years). The follow-up duration of all echocardiographic measurements was 14.4 ± 10.5 months after CRT. LAVI was measured from apical views on two-dimensional echocardiography by bi-plane rule. A decrease of left ventricular end systolic volume ≥ 15% after CRT was defined as a positive response to CRT. The mean LAVI at baseline was 59.9 ± 22.7 ml/m(2). LAVI in patients who died (78.2 ± 27.5 ml/m(2)) was significantly greater than those who survived (55.9 ± 19.5 ml/m(2), p<0.0001) during follow-up of 17 ± 10.6 months. The area under ROC curve (AUC) for LAVI predicting death was 0.77 (p=0.0001). The cutoff point for LAVI predicting death was LAVI>59.4 ml/m(2). LAVI>59.4 ml/m(2) was related to mortality by Cox proportional univariate regression [hazard ratio (HR)=5.15, 95% CI=1.48-17.93, p=0.01]. After adjustment for the variables with significant difference by univariate regression, LAVI>59.4 ml/m(2) was cont...Continue Reading

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Citations

Oct 16, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y WangY Shen
Oct 9, 2013·Heart Failure Reviews·Frederik H Verbrugge, Wilfried Mullens
May 9, 2012·International Journal of Cardiology·Alessandro MalagoliGiovanni Quinto Villani
Jun 4, 2013·International Journal of Cardiology·Luca RossiGiovanni Quinto Villani
Nov 5, 2016·European Journal of Heart Failure·Filippos TriposkiadisHarisios Boudoulas
Aug 26, 2014·Circulation. Arrhythmia and Electrophysiology·Yun-Jiu ChengSu-Hua Wu
Jan 27, 2017·The International Journal of Cardiovascular Imaging·Peter Bomholt HansenJens Cosedis Nielsen
Jul 18, 2017·Heart Failure Reviews·Donato MeleRoberto Ferrari

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