Impact of left ventricular remodeling and renal function on 24h-ECG recordings and cardiovascular outcome in elderly hypertensive patients

European Journal of Internal Medicine
Agata BuonaceraLorenzo Malatino

Abstract

The prognostic role of left ventricular remodeling and renal function in elderly hypertensive patients has been so far scarcely investigated. We assessed the impact of left ventricular geometry and renal function on 24h-Holter electrocardiogram (ECG) recordings and outcome in elderly hypertensive patients. We enrolled 251 asymptomatic hypertensive elderly patients (>65year-old). Left ventricular remodeling was evaluated by 2-D echocardiogram. Lown's class, mean QTc and standard deviation of all normal R-R intervals (SDNN) were assessed by 24-h Holter-ECG recordings. Data on all-cause and cardiovascular mortality were collected for 2years. Mean age was 76.2±11.4years. High Lown's classes were more frequently observed in the presence of left ventricular hypertrophy (LVH) (57.3% vs. 23.7%; p<0.001). Mean QTc was 444.8±34.8ms and resulted directly correlated with indexed left ventricular mass (r=0.228; p=0.001). Patients with Chronic Kidney Disease (CKD) showed lower SDNN as compared with those with preserved renal function (92.02±36.11ms vs. 103.84±33.96ms, respectively; p=0.017). At 2years, all-cause and cardiovascular mortality rates were 38.0% and 21.1%, respectively. Diabetes mellitus (HR: 2.40; 95% C.I.1.16 to 4.99; p=0.019),...Continue Reading

References

Sep 24, 1987·The New England Journal of Medicine·J M McLenachanH J Dargie
Jul 1, 1971·Circulation·B Lown, M Wolf
Mar 3, 2001·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·R Wolk
Mar 13, 2003·Kidney International·Guruprasad ManjunathMark J Sarnak
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Mar 28, 2006·The American Journal of Cardiology·Richard V MilaniFranz H Messerli
Jun 15, 2007·Journal of Hypertension·Oliver ZilchPeter J Blankestijn
Mar 6, 2009·Journal of Hypertension·Emilio NardiGiovanni Cerasola
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Oct 21, 2010·Circulation. Arrhythmia and Electrophysiology·Palaniappan Saravanan, Neil C Davidson
Feb 15, 2011·Trends in Pharmacological Sciences·Michael J CutlerDavid S Rosenbaum
Jul 19, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Preeti ChandraRajiv Saran
Nov 15, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Darshan DalalArthur A M Wilde
Nov 17, 2012·BMC Cardiovascular Disorders·Paolo MelilloLeandro Pecchia
May 30, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Ragesh PanikkathSumeet S Chugh
Nov 13, 2013·Progress in Cardiovascular Diseases·Heikki V Huikuri, Phyllis K Stein
Dec 21, 2013·American Journal of Nephrology·Paul E DrawzUNKNOWN CRIC Study Investigators
Feb 4, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gina-Marie BarlettaSusan Furth
May 16, 2014·Diabetes/metabolism Research and Reviews·Ildikó IstenesPéter Kempler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.