Impact of lipid-induced degradation on the mechanical properties of ultra-high molecular weight polyethylene for joint replacements

Journal of the Mechanical Behavior of Biomedical Materials
Hideyuki Sakoda, Shingo Niimi

Abstract

Gamma or electron beam irradiation of ultra-high molecular weight polyethylene (UHMWPE) used in artificial joints for sterilization and/or crosslinking purposes generates free radicals in the material, which causes long-term oxidative degradation of UHMWPE. Recently, another mechanism for the degradation of UHMWPE by the absorption of lipids during in vivo clinical use was proposed. However, knowledge on lipid-induced degradation is quite limited, compared with that on radical-induced degradation. In this study, lipid-induced degradation was simulated using squalene absorption and subsequent accelerated aging, and its impact on the mechanical properties of UHMWPE was evaluated. The simulated lipid-induced degradation caused an increased elastic modulus and decreased elongation with maximum degradation at the surfaces. These results imply that degradation of UHMWPE may occur during in vivo long-term use, even if free radicals are completely eliminated. Therefore, further investigation is required to clarify the impact of lipid-induced degradation on clinical outcomes, such as the wear and fatigue characteristics of UHMWPE components.

References

Feb 24, 2001·Biomaterials·L CostaL Trossarelli
Sep 14, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Miroslav SloufUwe Gohs
Dec 23, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ebru OralOrhun K Muratoglu

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Citations

Aug 2, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Mauro Fittipaldi, Landon R Grace
Feb 6, 2017·Journal of the Mechanical Behavior of Biomedical Materials·Mauro Fittipaldi, Landon R Grace
Feb 27, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hideyuki SakodaYuji Haishima
Jun 4, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hideyuki SakodaYuji Haishima
Dec 29, 2020·Journal of Biomaterials Applications·Fedra P ZaribafElise C Pegg

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