Impact of LMP7 (rs2071543) gene polymorphism in increasing cancer risk: evidence from a meta-analysis and trial sequential analysis

Oncotarget
Raju K MandalShafiul Haque

Abstract

Genetic variant LMP7 (low molecular weight polypeptide 7) -145 C > A may influence the function of immune surveillance of an individual and lead to cancer development. Various studies have investigated the relevance of LMP7 -145 C > A gene polymorphism with cancer risk; but, their results are conflicting and inconsistent. To obtain a comprehensive conclusion, a meta-analysis was performed by including eight eligible published studies retrieved from PubMed (Medline), EMBASE and Google Scholar web search until December 2016. Individuals with AA genotype (AA vs CC: p = 0.001; OR = 2.602, 95% CI = 1.780 to 3.803) of LMP7 -145 C > A were found to have 2 folds higher risk of cancer than those with CC genotype. The recessive genetic model (AA vs AC + CC) also indicated that individuals with AA genotype have 2 folds higher cancer risk than AC and CC genotypes (p = 0.001; OR = 2.216, 95% CI = 1.525 to 3.221). Also, significant increased cancer risk was observed in Asians but not in Caucasians. No publication bias was observed during the analysis. Trial sequential analysis also strengthened our current findings. These results suggest that genetic variant LMP7-145 C > A has significant role in increasing cancer risk in overall and Asian p...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 1, 1995·Annual Review of Biochemistry·M T Heemels, H Ploegh
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jun 1, 1955·Annals of Human Genetics·B WOOLF
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Derek AtkinsBarbara Seliger
Nov 2, 2004·Nature Reviews. Cancer·Paul D P PharoahDouglas F Easton
Sep 9, 2006·Science·Tobias SjöblomVictor E Velculescu
Mar 17, 2007·Genes, Chromosomes & Cancer·Akash M MehtaGert J Fleuren
Apr 28, 2007·Chemistry & Biology·Yik Khuan HoKyung-Bo Kim
May 26, 2007·Journal of Clinical Immunology·Changqing XuBangwei Cao
Dec 18, 2007·Journal of Clinical Epidemiology·Jørn WetterslevChristian Gluud
Aug 5, 2008·International Journal of Epidemiology·Paul R BurtonPaul Elliott
Sep 6, 2008·Science·D Williams ParsonsKenneth W Kinzler
Jul 30, 2009·Human Mutation·Sevtap Savas, Geoffrey Liu
Nov 13, 2009·Carcinogenesis·Charles C ChungStephen J Chanock
Apr 19, 2011·Nature Genetics·Xiaomu WeiYardena Samuels
Jun 5, 2012·Japanese Journal of Clinical Oncology·Hai-Rim ShinCherian Varghese
Jul 20, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Jun 4, 2013·Annual Review of Genomics and Human Genetics·Orestis A PanagiotouJohn P A Ioannidis
Jan 1, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Filiz Ozbas-GercekerSibel Oguzkan-Balci
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Methods Mentioned

BETA
Genotyping
Assay

Software Mentioned

Google Scholar
TSA Trial sequential analysis tool
Comprehensive Meta - Analysis ( CMA )
Trial Sequential Analysis ( TSA )
PRISMA
Trial Sequential Analysis
EMBASE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved