Impact of Long-Acting Somatostatin Analogues on Glucose Metabolism in Acromegaly: A Hospital-Based Study

International Journal of Endocrinology
Ming ShenZhaoyun Zhang

Abstract

To evaluate the change in glucose tolerance in treatment-naïve patients with acromegaly after administration of SSA and to identify predictive factors of glucose impairment during SSA therapy. Oral glucose tolerance testing (OGTT) was performed on 64 newly diagnosed and treatment-naïve patients with acromegaly both at pretreatment and 3 months after initiation of treatment with long-acting SSA. Insulin resistance (IR) was assessed by homeostatic model assessment- (HOMA-) IR and ISOGTT. Insulin secretion was assessed by HOMA-β, INS0/BG0, IGI (insulinogenic index), IGI/IR, ISSI2, and AUCINS/AUCBG. Receiver-operating characteristic (ROC) curves were generated to determine the optimal cutoffs to predict the impact of SSA on glucose metabolism. Pretreatment, 19, 24, and 21 patients were categorized as having normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and diabetes mellitus (DM), respectively. Posttreatment, IR, represented by ISOGTT, was significantly improved in all 3 groups. Insulin secretion, represented by HOMA-β, declined in the NGT and IGT groups, but was unaltered in the DM group. The glucose tolerance status deteriorated in 18 (28.1%) patients, including 13 patients in the NGT group and 5 patients in th...Continue Reading

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Citations

Jan 14, 2020·The Journal of Clinical Endocrinology and Metabolism·Meng WangZhaoyun Zhang
Aug 17, 2019·Frontiers in Endocrinology·Greisa VilaGünter K Stalla
Aug 25, 2020·International Journal of Endocrinology·Jing GuZhiwen Yin
Oct 22, 2020·Pituitary·Betina BiagettiRafael Simó
Jul 8, 2020·Expert Opinion on Pharmacotherapy·Sylvère Störmann, Jochen Schopohl

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