Impact of long-axis function on cardiac surgical outcomes in patients with radiation-associated heart disease

The Journal of Thoracic and Cardiovascular Surgery
Srisakul ChirakarnjanakornMilind Y Desai

Abstract

Malignancy-associated thoracic radiation leads to radiation-associated cardiac disease (RACD) that often necessitates cardiac surgery. Myocardial dysfunction is common in patients with RACD. We sought to determine the predictive value of global left ventricular ejection fraction and long-axis function left ventricular global longitudinal strain (LV-GLS) in such patients. We studied 163 patients (age, 63 ± 14 years; 74% women) who had RACD and underwent cardiac surgery (20% had reoperations) between 2000 and 2003. In addition to standard echocardiography, LV-GLS (%) was derived from the average of 18 segments in 3 apical views of the left ventricle, using velocity vector imaging. Standard clinical and demographic parameters were recorded. All-cause mortality was recorded. The mean duration between cardiac surgery and the last chest radiation was 18 ± 12 years. The median European System for Cardiac Operative Risk Evaluation (EuroSCORE) was 8, and 88 patients died over 6.6 ± 4 years. A total of 52% of patients had ≥ II+ mitral regurgitation; 23% of patients had severe aortic stenosis; and 39% of patients had ≥ II+ tricuspid regurgitation. The mean left ventricular ejection fraction was 54% ± 13%, and the mean LV-GLS was -12.9% ± ...Continue Reading

References

Mar 1, 1991·Progress in Cardiovascular Diseases·M A Arsenian
Jan 1, 1995·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·D ReberP Tollenaere
Oct 27, 1993·JAMA : the Journal of the American Medical Association·S L HancockR T Hoppe
Mar 6, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C GlanzmannP Huguenin
May 16, 1998·The Annals of Thoracic Surgery·R S Veeragandham, M D Goldin
May 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·N HandaF J Puga
Aug 24, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S A NashefR Salamon
Sep 14, 1999·Journal of the American College of Cardiology·M S LauerE J Topol
Jun 28, 2001·The Annals of Thoracic Surgery·N HandaF J Puga
Jul 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·William A ZoghbiUNKNOWN American Society of Echocardiography
Aug 7, 2003·Seminars in Radiation Oncology·M Jacob AdamsLouis S Constine
Aug 23, 2003·Journal of the American College of Cardiology·Paul A HeidenreichIngela Schnittger
Sep 1, 2004·The Annals of Thoracic Surgery·Juan A CrestanelloHartzell V Schaff
Jan 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Albert S Y ChangBruce W Lytle
Jan 12, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shemy CarassoHarry Rakowski
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Mar 10, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Sherif F NaguehArturo Evangelisa
Apr 10, 2009·JACC. Cardiovascular Imaging·Thomas H MarwickJames D Thomas
Feb 16, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shemy CarassoHarry Rakowski
Mar 18, 2010·Circulation. Cardiovascular Imaging·Julien NahumPascal Lim
Jul 24, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Hua YangHarry Rakowski
Aug 8, 2012·Circulation. Cardiovascular Imaging·Jordi S DahlJacob E Møller

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Citations

Mar 21, 2015·The Journal of Thoracic and Cardiovascular Surgery·James I Fann
Jun 5, 2019·Current Treatment Options in Cardiovascular Medicine·Katherine Lee ChuyDipti Gupta
Sep 2, 2019·Current Treatment Options in Cardiovascular Medicine·Agostina M FavaMilind Y Desai
Mar 23, 2021·Journal of the American Heart Association·Siddharth J TrivediLiza Thomas

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