Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry

Diabetologia
Stefanie LanzingerReinhard W Holl

Abstract

Studies on the association between air pollution and metabolic control in children and adolescents with type 1 diabetes are rare and findings are inconsistent. We examined the relationship between air pollution variables (particulate matter with an aerodynamic diameter <10 μm [PM10], NO2 and accumulated ozone exposure [O3-AOT]) and metabolic variables (HbA1c and daily insulin dose [U/kg body weight]) in children and adolescents with type 1 diabetes. We investigated 37,372 individuals with type 1 diabetes aged <21 years, documented between 2009 and 2014 in 344 German centres of the prospective diabetes follow-up registry (Diabetes-Patienten-Verlaufsdokumentation [DPV]). Long-term air pollution exposure (annual and quinquennial means) data were linked to participants via the five-digit postcode areas of residency. Cross-sectional multivariable regression analysis was used to examine the association between air pollution and metabolic control. After comprehensive adjustment, an interquartile range increase in O3-AOT was associated with a lower HbA1c (-3.7% [95% CI -4.4, -3.0]). The inverse association between O3-AOT and HbA1c persisted after additional adjustment for degree of urbanisation or additional adjustment for PM10. Moreov...Continue Reading

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Citations

Nov 30, 2019·International Journal of Environmental Research and Public Health·Ming ZengWeike Zhang
Dec 24, 2018·Frontiers in Immunology·Chelsea A O'Driscoll, Joshua D Mezrich
Jun 12, 2019·International Journal of Environmental Research and Public Health·Esha BansalRoberto G Lucchini
Jul 22, 2019·Current Diabetes Reports·Chris C Lim, George D Thurston
Apr 19, 2021·Environment International·Alaa Taha-KhaldeLena Novack
Sep 28, 2021·Critical Reviews in Toxicology·Judy S LaKindSatori A Marchitti

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