Impact of long-term naltrexone treatment on growth hormone and insulin secretion in hyperandrogenic and normal obese patients

Metabolism: Clinical and Experimental
P VillaA Lanzone

Abstract

The growth hormone (GH) response to stimulation tests is impaired in obesity. Moreover, obese patients exhibit a "paradoxical" increase of GH to GH-releasing hormone (GHRH) stimulation after food ingestion; this paradoxical response is reversed by naloxone infusion. On the other hand, beta-endorphin seems to exert profound effects on insulin release. Recent studies also demonstrated an impairment of GH response to several stimuli in polycystic ovary syndrome (PCOS), a condition associated with obesity, hyperinsulinism, and insulin resistance. Chronic inhibition of opioid tone by the opioid antagonist naltrexone (NTX) is able to reduce the insulin response to an oral glucose tolerance test (OGTT) in hyperinsulinemic PCOS patients. Since insulin and GH may reciprocally influence their secretion and the opioid system may have a role in the pathogenesis of hyperinsulinemia and reduced GH secretion, we have explored the involvement of these neuroendocrine mechanisms in essential obesity and in obesity associated with hyperandrogenism by a long-term treatment with an opiate antagonist. We tested seven obese patients affected by PCOS, seven matched women with essential obesity (EO), and five non-obese control subjects. All patients, i...Continue Reading

References

Oct 1, 1979·The Journal of Clinical Endocrinology and Metabolism·J F BruniS S Yen
Jan 1, 1991·Hormone Research·F CordidoC Dieguez
Jan 1, 1989·The Medical Clinics of North America·G A Bray
May 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D ScavoR Genazzani
Aug 1, 1988·Fertility and Sterility·R L BarbieriK J Ryan
May 1, 1987·Endocrinology·R E IsaacsJ D Baxter
Feb 13, 1982·Lancet·H A SternbachM S Gold
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·M I NewL S Levine
Nov 1, 1984·Clinics in Endocrinology and Metabolism·R Jung
May 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J R GivensA E Kitabchi
Apr 1, 1981·Fertility and Sterility·J W Goldzieher
Feb 1, 1981·The Australian & New Zealand Journal of Obstetrics & Gynaecology·J S Biggs
Apr 1, 1981·Clinical Endocrinology·A GrossmanG M Besser
Apr 1, 1982·The Journal of Clinical Endocrinology and Metabolism·J S Mason, D Heber
Apr 1, 1994·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R VettorG Federspil
Sep 1, 1995·Human Reproduction·A M FulghesuS Mancuso

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