Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes

International Journal of Cardiology
Ji Young ParkDong Joo Oh

Abstract

High dose atorvastatin is known to be associated with new onset diabetes mellitus (NODM) in patients with high risk for developing diabetes mellitus (DM). However, low dose atorvastatin is more commonly used as compared with high dose atorvastatin. The aim of this study is to investigate the impact of low dose atorvastatin (LDA, 10mg or 20mg) on the development of NODM up to three years in Asian patients. From January 2004 to September 2009, we investigated a total of 3566 patients who did not have DM. To adjust for potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. After PSM (C-statistics: 0.851), a total of 818 patients (LDA group, n=409 patients and control group, n=409 patients) were enrolled for analysis. Before PSM, the cumulative incidence of NODM (5.8% vs. 2.1%, p<0.001), myocardial infarction (0.5% vs. 0.1%, p-value=0.007), and major adverse cardio-cerebral event (MACCE, 1.8% vs. 0.7%, p-value=0.012) at three-years were higher in the LAD group. However, after PSM, there was a trend toward higher incidence of NODM (5.9% vs. 3.2%, p=0.064) in the LDA group, but the incidence of MACCE (1.2% vs. 1.5%, p-value=1.000) was similar between the two groups. In mul...Continue Reading

References

Nov 5, 2008·Journal of Atherosclerosis and Thrombosis·Tadashi YamakawaYasuo Terauchi
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Dec 7, 2010·Atherosclerosis·Kwang Kon KohMichael J Quon
Jun 23, 2011·JAMA : the Journal of the American Medical Association·David PreissKausik K Ray
Oct 14, 2011·International Journal of Cardiology·Kwang Kon KohMichael J Quon
Jan 4, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jun 29, 2014·Atherosclerosis·Soo LimKwang Kon Koh

❮ Previous
Next ❯

Citations

Jan 7, 2016·The American Journal of Cardiology·Seung-Woon RhaDong Joo Oh
Apr 5, 2018·Cardiorenal Medicine·Haroon KamranSamy I McFarlane
Dec 22, 2017·Clinical and Experimental Pharmacology & Physiology·Byoung Geol ChoiSeung-Woon Rha
Mar 13, 2020·Diabetes/metabolism Research and Reviews·Srikanth TangellojuScott LaJoie
Dec 20, 2020·Clinical and Experimental Pharmacology & Physiology·Byoung Geol ChoiSunghoi Hong
Mar 22, 2021·BMC Medical Informatics and Decision Making·Xuchun WangLixia Qiu
Apr 19, 2017·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M CasulaA L Catapano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.