Impact of Low-Dose Occupational Exposure to Ionizing Radiation on T-Cell Populations and Subpopulations and Humoral Factors Included in the Immune Response

Dose-response : a Publication of International Hormesis Society
Ilona Mihaylova GyulevaIvanka Tankova Rupova

Abstract

The aim of the present study is to assess the effects of low-dose occupational exposure on T helper response. One Hundred five employees working in Nuclear Power Plant, Kozloduy, Bulgaria and control group of 32 persons are included in this investigation. Flow cytometry measurements of T-cell populations and subpopulations and natural killer T cells are performed and levels of G, A, and M immunoglobulins and interleukin 2 (IL-2), IL-4, and interferon γ were determined. The data interpreted with regard to cumulative doses, length of service, and age. The results of the present study are not enough to outline a clear impact of occupational radiation exposure on T helper populations. Nevertheless, the observed even slight trends in some lymphocyte's populations and in cytokines profile give us the reason to assume a possibility of a gradual polarization of T helper 1 to T helper 2 immune response at dose range 100 to 200 mSv. The results of the present study indicate the need to perform a more detailed epidemiological survey including potential confounding and misclassifying factors and possible selection bias that could influence the results.

References

Jun 18, 2003·Critical Reviews in Toxicology·Shu-Zheng Liu
Aug 7, 2003·Seminars in Radiation Oncology·Jacqueline WilliamsPaul Okunieff
Oct 8, 2003·International Journal of Radiation Oncology, Biology, Physics·Annette SchmitzGilles Thomas
Aug 25, 2004·Archives of Medical Research·Ahmet GodekmerdanSelami Serhatlioglu
Jan 11, 2005·The American Journal of Medicine·Tomonori HayashiKei Nakachi
Apr 28, 2006·International Journal of Radiation Biology·Hae-Ran ParkSang-Gi Paik
Apr 11, 2007·Cellular Immunology·Hongwei RenToru Abo
Jun 4, 2010·Occupational Medicine·F ZakeriK Akbari Noghabi
Aug 24, 2010·Radiation Research·Eniko Noémi BogdándiKatalin Lumniczky
Dec 7, 2010·Radiation Research·Yoichiro KusunokiKei Nakachi
Oct 15, 2011·Immunotherapy·Jeff J SubleskiRobert H Wiltrout
Aug 9, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tomonori HayashiKei Nakachi
Jul 31, 2014·Radiation and Environmental Biophysics·Valentina L RybkinaAlexander V Zurochka
Jan 8, 2016·Dose-response : a Publication of International Hormesis Society·Ilona Mihaylova GyulevaJana Nikolaeva Djounova

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Citations

Dec 20, 2020·International Journal of Radiation Oncology, Biology, Physics·Clayton B HessMohammad K Khan
Dec 10, 2020·Environment International·Katalin LumniczkyDörthe Schaue

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Methods Mentioned

BETA
gamma
flow cytometry
enzyme-linked immunosorbent assay
ELISA
X-ray

Software Mentioned

Cell Quest

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