Impact of Magnetic Resonance Imaging on Gross Tumor Volume Delineation in Non-spine Bony Metastasis Treated With Stereotactic Body Radiation Therapy

International Journal of Radiation Oncology, Biology, Physics
Srinivas RamanChia-Lin Tseng

Abstract

This study investigates the inter-observer variability of contouring non-spine bone metastases using the planning CT alone vs. the addition of MRI T1 and T2 imaging sequences. 10 cases of non-spine bone metastases treated with SBRT at our institution were selected. The gross tumor volume (GTV) for each case was delineated by six SBRT radiation oncologists (RO) and one diagnostic radiologist (DR) on the treatment planning CT. After a minimum of three months, each case was re-contoured on the CT fused with a MRI T1 sequence followed by a MRI T2 sequence. STAPLE consensus contours were created from the RO volumes and inter-observer variability was measured using both κ agreement and the Dice coefficient (DSC). In total, 180 RO contours were analyzed within three datasets (CT, CT + MRI T1 and CT + MRI T1 + MRI T2). The mean GTV was 16.95 cm3 (range, 0.12-269.6 cm3). The RO κ agreement was 0.6129 based on CT alone, and significantly increased to 0.7045 in the CT + MRI T1 (P = .042) dataset and 0.7017 in the CT + MRI T1 + MRI T2 dataset (P = .048). The mean DSC in the CT alone dataset was 0.7047, and significantly increased to 0.7628 in the CT + MRI T1 dataset (P < .001) and 0.7544 in the CT + MRI T1 + MRI T2 dataset (P = .001). Ther...Continue Reading

Citations

Oct 27, 2020·Journal of Medical Radiation Sciences·Jason A Dowling, Laura M O'Connor
Nov 23, 2020·Medical Oncology·Carolina De la Pinta
Jan 11, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A IlamuruguR Velayudham
Oct 18, 2020·Practical Radiation Oncology·Kei ItoKatsuyuki Karasawa
Jul 17, 2021·International Journal of Computer Assisted Radiology and Surgery·Ali AtaeiEsther Tanck
Aug 30, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yilin CaoKristin J Redmond
Oct 12, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F Lopez-CamposA Conde-Moreno
Dec 1, 2021·Journal of Applied Clinical Medical Physics·Fang LiMohammed Saiful Huq

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