Impact of malondialdehyde-modified low-density lipoprotein on clinical outcomes after fractional flow reserve-guided deferral of revascularization.

Heart and Vessels
Masashi YokoiNobuyuki Ohte

Abstract

Cardiovascular events can occur after deferred revascularization, and malondialdehyde-modified low-density lipoprotein (MDA-LDL) has been suggested to be an atherogenic marker. We investigated the relationship between serum MDA-LDL levels and clinical outcomes in patients with fractional flow reserve (FFR)-guided deferral of revascularization. Among 3084 patients undergoing coronary angiography, we retrospectively analyzed 127 patients with intermediate stenosis and deferred revascularization based on FFR > 0.80. Median follow-up interval was 30.4 months, and serum MDA-LDL was measured prior to the measurement of FFR. We evaluated the composite of major adverse cardiac events (MACEs), including cardiac death, myocardial infarction, ischemia-driven deferred lesion revascularization, and any revascularization. MACEs occurred in 18 (14.2%) patients. The MACE group presented with significantly higher MDA-LDL levels than the non-MACE group (134.9 ± 33.3 U/L vs. 95.6 ± 32.2 U/L, P < 0.001). In analysis of the receiver operating characteristics curve for the prediction of MACEs, MDA-LDL presented a significantly larger area under the curve than low-density lipoprotein-cholesterol (LDL-C; 0.810 vs. 0.687, P = 0.042). Univariate Cox reg...Continue Reading

References

Jun 27, 1996·The New England Journal of Medicine·N H PijlsJ J Koolen
Nov 13, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Nageswara R MadamanchiMarschall S Runge
Jun 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Klaus LeyCatherine C Hedrick
Dec 18, 2013·Journal of Atherosclerosis and Thrombosis·Tamio TeramotoUNKNOWN Japan Atherosclerosis Society Committee for Epidemiology and Clinical Management of Atherosclerosis
Nov 26, 2016·Journal of the American College of Cardiology·Emanuele BarbatoBernard De Bruyne
Apr 30, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuhiro TanakaUNKNOWN CVIT-DEFER Registry Investigators
May 23, 2018·The New England Journal of Medicine·Panagiotis XaplanterisUNKNOWN FAME 2 Investigators
Aug 24, 2018·Journal of Atherosclerosis and Thrombosis·Makoto KinoshitaUNKNOWN Committee for Epidemiology and Clinical Management of Atherosclerosis
Aug 30, 2018·Journal of the American College of Cardiology·Kristian ThygesenUNKNOWN Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American He
Aug 31, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Masashi YokoiNobuyuki Ohte

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.