Abstract
Cardiovascular events can occur after deferred revascularization, and malondialdehyde-modified low-density lipoprotein (MDA-LDL) has been suggested to be an atherogenic marker. We investigated the relationship between serum MDA-LDL levels and clinical outcomes in patients with fractional flow reserve (FFR)-guided deferral of revascularization. Among 3084 patients undergoing coronary angiography, we retrospectively analyzed 127 patients with intermediate stenosis and deferred revascularization based on FFR > 0.80. Median follow-up interval was 30.4 months, and serum MDA-LDL was measured prior to the measurement of FFR. We evaluated the composite of major adverse cardiac events (MACEs), including cardiac death, myocardial infarction, ischemia-driven deferred lesion revascularization, and any revascularization. MACEs occurred in 18 (14.2%) patients. The MACE group presented with significantly higher MDA-LDL levels than the non-MACE group (134.9 ± 33.3 U/L vs. 95.6 ± 32.2 U/L, P < 0.001). In analysis of the receiver operating characteristics curve for the prediction of MACEs, MDA-LDL presented a significantly larger area under the curve than low-density lipoprotein-cholesterol (LDL-C; 0.810 vs. 0.687, P = 0.042). Univariate Cox reg...Continue Reading
References
Nov 17, 1994·Biochimica Et Biophysica Acta·K KotaniM Manabe
Jun 27, 1996·The New England Journal of Medicine·N H PijlsJ J Koolen
Sep 16, 2004·Heart·T AmakiR Nagai
Nov 13, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Nageswara R MadamanchiMarschall S Runge
Jun 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Klaus LeyCatherine C Hedrick
May 11, 2012·European Heart Journal Cardiovascular Imaging·Yoshiki MatsuoTakashi Akasaka
Dec 18, 2013·Journal of Atherosclerosis and Thrombosis·Tamio TeramotoUNKNOWN Japan Atherosclerosis Society Committee for Epidemiology and Clinical Management of Atherosclerosis
Feb 16, 2015·Atherosclerosis·Tsuyoshi ItoNobuyuki Ohte
Aug 21, 2015·Journal of the American Heart Association·Shriti Masrani MehtaHoward I Kurz
Sep 25, 2015·European Heart Journal·Frederik M ZimmermannNico H J Pijls
Jul 20, 2016·Cardiovascular Diabetology·Mark W KennedyElvin Kedhi
Nov 26, 2016·Journal of the American College of Cardiology·Emanuele BarbatoBernard De Bruyne
Apr 30, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuhiro TanakaUNKNOWN CVIT-DEFER Registry Investigators
Oct 27, 2017·Heart and Vessels·Tsuyoshi ItoNobuyuki Ohte
May 23, 2018·The New England Journal of Medicine·Panagiotis XaplanterisUNKNOWN FAME 2 Investigators
Jun 26, 2018·International Journal of Cardiology·Umberto BarberoJavier Escaned
Jul 26, 2018·Journal of cardiology·Nobuhiro TanakaMasato Nakamura
Aug 24, 2018·Journal of Atherosclerosis and Thrombosis·Makoto KinoshitaUNKNOWN Committee for Epidemiology and Clinical Management of Atherosclerosis
Aug 30, 2018·Journal of the American College of Cardiology·Kristian ThygesenUNKNOWN Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American He
Sep 20, 2018·Heart and Vessels·Rikuta HamayaTsunekazu Kakuta
Feb 14, 2020·European Heart Journal·Jan BorénHenry N Ginsberg
Aug 31, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Masashi YokoiNobuyuki Ohte