Impact of marathon running on cardiac structure and function in recreational runners

Clinical Science
Gregory WhyteRickie Simspon

Abstract

The present study examined the relationship between LV (left ventricular) function, markers of cardiac-specific damage and markers of oxidative stress in recreational runners following a marathon. Runners (n=52; 43 male and nine female; age, 35+/-10 years; height, 1.74+/-0.08 m; body mass, 75.9+/-8.9 kg) were assessed pre- and immediately post-marathon. LV function was assessed using standard M-mode two-dimensional Doppler echocardiography and TDI (tissue-Doppler imaging) echocardiography. Serum was analysed for cTnT (cardiac troponin-T), TEAC (Trolox equivalent antioxidant capacity; a measure of total antioxidant capacity), MDA (malondealdehyde) and 4-HNE (4-hydroxynonenal). A strong relationship was observed between standard and TDI echocardiography for all functional measures. Diastolic function was altered post-marathon characterized by a reduction in E (peak early diastolic filling: 0.79+/-0.11 compared with 0.64+/-0.16 cm/s; P<0.001), an increase in A (peak late diastolic filling: 0.48+/-0.11 compared with 0.60+/-0.12 cm/s; P<0.001) and a resultant decrease in E/A (ratio of E to A; 1.71+/-0.48 compared with 1.10+/-0.31; P<0.001). Ejection fraction remained unchanged post-marathon. Thirty-two runners presented with cTnT va...Continue Reading

References

Jul 1, 1975·The Journal of Clinical Investigation·W GrossmanL P McLaurin
Mar 1, 1991·British Journal of Sports Medicine·A J Ryan
Jan 1, 1991·Anesthesiology·J L RobothamY Harasawa
Dec 1, 1987·Circulation·P S DouglasN Reichek
Nov 27, 1982·British Medical Journal·E M OhmanJ H Horgan
Aug 1, 1993·Sports Medicine·W J Rowe
May 1, 1996·International Journal of Sports Medicine·A BonettiG Tredici
Feb 1, 1996·Journal of Applied Physiology·S B EysmannP S Douglas
Aug 1, 1997·Journal of the American College of Cardiology·V G Dávila-RománA S Jaffe
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Aug 11, 1999·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·M AlamR Nordlander
Oct 20, 1999·Medicine and Science in Sports and Exercise·A LucíaJ L Chicharro
Jun 22, 2000·Medicine and Science in Sports and Exercise·G P WhyteW J McKenna
Feb 13, 2001·The American Journal of Cardiology·G NeumayrH Hoertnagl
Oct 6, 2001·Annals of Clinical Biochemistry·P O CollinsonD C Gaze
Oct 26, 2001·The American Journal of Cardiology·A J SiegelK B Lewandrowski
Jul 18, 2002·Heart & Lung : the Journal of Critical Care·Jonathan M McGavockMark J Haykowsky
Apr 17, 2003·Sports Medicine·Ellen DawsonDerek Ball
May 31, 2003·Scottish Medical Journal·R E ShaveP Collinson
Nov 5, 2003·Heart·P O Collinson, P J Stubbs
May 1, 2004·BMJ : British Medical Journal·Peter AmmannHans Rickli

❮ Previous
Next ❯

Citations

Oct 13, 2009·European Journal of Applied Physiology·Keith P GeorgeDaniel J Green
May 24, 2011·European Journal of Applied Physiology·Stéphane NottinNicolas Tordi
Oct 15, 2011·European Journal of Applied Physiology·Tanja OosthuyseAngela J Woodiwiss
Dec 2, 2008·European Heart Journal·Gordon L Pierpont, Edward O McFalls
Jul 6, 2010·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Rory O'HanlonSanjay K Prasad
Mar 21, 2008·Diagnostic Pathology·Shaheen E Lakhan, Lindsey Harle
May 28, 2013·BMC Research Notes·Enrique Serrano OstarizAlejandro Legaz Arrese
Nov 22, 2011·Vascular Health and Risk Management·Asli Tanindi, Mustafa Cemri
Aug 6, 2013·The Canadian Journal of Cardiology·Valerie GaudreaultEric Larose
May 15, 2012·The American Journal of Cardiology·Natthapon TraipermMartin Burtscher
Jan 24, 2016·The Journal of Physiology·Glenn M StewartSurendran Sabapathy
Sep 4, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Emma HartDavid Oxborough
Jan 16, 2007·International Journal of Cardiology·Natalie MiddletonDavid Gaze
Jul 29, 2010·Journal of Interventional Cardiology·Steven RegwanAhmad M Slim
Nov 19, 2011·Scandinavian Journal of Medicine & Science in Sports·F Chan-DewarK George
Aug 4, 2010·Echocardiography·David OxboroughKeith George
Dec 4, 2014·Journal of Science and Medicine in Sport·Kuno HottenrottFrank-Stephan Jäger
May 31, 2006·Gastrointestinal Endoscopy·Amit Rastogi, Donald R Campbell
May 14, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Tanja Oosthuyse, Aletta M E Millen
Jun 16, 2016·Journal of Veterinary Internal Medicine·M FlethøjR Buhl
Jul 16, 2016·International Journal of Cardiology·T Gresslien, S Agewall
Jun 4, 2017·Physiological Reports·Maria F ArisiJoseph R Libonati
Oct 8, 2009·Circulation. Cardiovascular Imaging·Stéphane NottinPhilippe Obert
May 9, 2006·Medicine and Science in Sports and Exercise·Natalie MiddletonGreg Atkinson
Jan 16, 2007·Medicine and Science in Sports and Exercise·Natalie MiddletonDavid Gaze
Apr 18, 2008·Sports Medicine·Etienne C H J MichielsenMarja P Van Dieijen-Visser
Nov 30, 2007·Medicine and Science in Sports and Exercise·Robert ShavePaul O Collinson
Apr 8, 2006·Current Opinion in Cardiology·Peter C Frommelt
Mar 24, 2006·European Heart Journal·Tomas G NeilanMalissa J Wood
Jun 14, 2006·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Keith GeorgeEllen Dawson
Aug 23, 2008·Journal of Applied Physiology·Ellen A DawsonDaniel J Green
Jun 20, 2019·Medicina·Renata Žumbakytė-ŠermukšnienėKristina Berškienė
Feb 24, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Rob ShaveDavid Oxborough
Jan 25, 2020·Clinical Cardiology·George A Stavroulakis, Keith P George
Jul 11, 2008·Medicine and Science in Sports and Exercise·Jürgen ScharhagWilfried Kindermann
Feb 28, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Claire MaufraisStéphane Nottin
Jul 11, 2008·Medicine and Science in Sports and Exercise·Rob ShaveNatalie Middleton
Jul 11, 2008·Medicine and Science in Sports and Exercise·Gregory P Whyte

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.