Impact of meal timing and frequency on the twenty-four-hour leptin rhythm

Hormone Research
A J FogtelooA E Meinders

Abstract

To study the influence of changes in meal timing and frequency on the diurnal rhythm of leptin and on the 24-hour profile of insulin and glucose. Five obese women were studied twice during a weight-maintaining diet in either 3 daily or 8 day and night equal portions. Blood was sampled for 24-hour profiles of leptin and insulin. During the 8-meal intervention, the 24-hour rhythm of leptin changed significantly: the amplitude decreased (p = 0.0089) and the acrophase was delayed by 168 min (p = 0.021). Also, 8 small insulin secretion peaks occurred instead of the 3 postprandial high insulin peaks. The dispersion of food intake over 24 h affects the diurnal leptin rhythm. These changes could not be attributed to changes in circadian timing or energy balance. Instead, changes in daily insulin secretion profiles might play a role.

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Citations

Dec 13, 2007·Annals of Nutrition & Metabolism·Hope BarkoukisJohn P Kirwan
Jan 20, 2009·Journal of Biological Rhythms·Namni GoelDavid F Dinges
Oct 3, 2006·Breast Cancer Research : BCR·Anne StuedalInger T Gram
Jul 16, 2008·Sports Medicine·Greg AtkinsonDon Maclaren
Jul 2, 2009·Nutrition Reviews·Michelle A PalmerSurinder K Baines
Oct 4, 2006·Research in Veterinary Science·Zeki YilmazEsin Golcu
Apr 22, 2015·International Journal of Endocrinology·M A UlhôaC R C Moreno
Dec 13, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Johann DaxerMirja Quante

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