Impact of mechanical stretch on the cell behaviors of bone and surrounding tissues

Journal of Tissue Engineering
Hye-Sun YuIvan Wall

Abstract

Mechanical loading is recognized to play an important role in regulating the behaviors of cells in bone and surrounding tissues in vivo. Many in vitro studies have been conducted to determine the effects of mechanical loading on individual cell types of the tissues. In this review, we focus specifically on the use of the Flexercell system as a tool for studying cellular responses to mechanical stretch. We assess the literature describing the impact of mechanical stretch on different cell types from bone, muscle, tendon, ligament, and cartilage, describing individual cell phenotype responses. In addition, we review evidence regarding the mechanotransduction pathways that are activated to potentiate these phenotype responses in different cell populations.

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Citations

Feb 6, 2017·Atlas of the Oral and Maxillofacial Surgery Clinics of North America·Susan K Snyder, Larry L Cunningham
Mar 30, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tao WangMing H Zheng
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Jul 8, 2020·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Agnes SchröderChristian Kirschneck
Aug 14, 2019·Tissue Engineering. Part C, Methods·Amir Monemian EsfahaniRuiguo Yang
Feb 10, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Mohammad Saber HashemiAzadeh Sheidaei

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Methods Mentioned

BETA
nuclear translocation
transfection

Software Mentioned

Flexercell

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