Impact of metastases on nodal immunoreactivity in head and neck cancer

The Laryngoscope
D E SchullerG E Milo

Abstract

It has been previously demonstrated by the authors that lymph nodes from patients with head and neck cancer are capable of regional immunoreactivity and that this immunoreactivity could be enhanced with certain nonspecific immunostimulants. However, it is unknown how metastases to the neck nodes would affect this immunoreactivity. The purpose of this study is to compare the immunoreactivity of matched node pairs (metastatic versus nonmetastatic) from head and neck cancer patients. The soft agar assay system was the methodology employed. The effect of nodal lymphocytes on tumor growth in soft agar was studied with and without nonspecific immunostimulation in both normal and metastatic nodes from the same location in the neck in 16 patients. The results demonstrate that lymph nodes from head and neck cancer patients are capable of an immune reaction to cancer, and that this immunoreactivity appears to be significantly increased in metastatic lymph nodes with and without the use of specific immunostimulants.

References

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Citations

Jul 1, 1989·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P S MuraliS G Gangal
Oct 30, 2004·Acta Oto-laryngologica·Antonio SarnoOreste Gallo
Jan 10, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Emma VerasteguiGuillermo Alfaro

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