Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumonia

American Journal of Respiratory and Critical Care Medicine
Alain CombesPneumA Trial Group

Abstract

The impact of methicillin resistance on morbidity and mortality of patients suffering from severe Staphylococcus aureus infections remains highly controversial. We analyzed a retrospective cohort of 97 patients with methicillin-susceptible and 74 patients with methicillin-resistant Staphylococcus aureus ventilator-associated pneumonia (VAP). Initial empiric antibiotic therapy was appropriate for every patient. Patients with methicillin-resistant Staphylococcus aureus VAP were older, had higher disease-severity scores, and had been on mechanical ventilation longer at onset of VAP. Factors associated with 28-day mortality retained by multivariate logistic regression analysis were: age (odds ratio [OR] = 1.05, 95% confidence interval [CI], 1.02-1.08, p = 0.001) and Day 1 organ dysfunctions or infection (ODIN) score (OR = 1.90, 95% CI, 1.31-2.78, p = 0.001), but not methicillin resistance (OR = 1.72, 95% CI, 0.73-4.05, p = 0.22). The percentages of infection relapse or superinfection did not differ significantly between the two patient groups. In conclusion, after controlling for clinical and physiologic heterogeneity between groups, methicillin resistance did not significantly affect 28-day mortality of patients with Staphylococcu...Continue Reading

References

Jun 1, 1990·Antimicrobial Agents and Chemotherapy·P M Small, H F Chambers
Dec 1, 1994·American Journal of Respiratory and Critical Care Medicine·J RelloR Rodriguez-Roisin
Dec 22, 1993·JAMA : the Journal of the American Medical Association·J R Le GallF Saulnier
Dec 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Romero-VivasJ J Picazo
Nov 1, 1996·The Journal of Antimicrobial Chemotherapy·M CrucianiE Concia
Feb 25, 1998·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·L O ConternoA Castelo
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·J L TrouilletC Gibert
Oct 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C GonzálezJ J Picazo
Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A SorianoE Soriano
Nov 14, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J M Mylotte, A Tayara
Nov 18, 2000·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·L A SelveyB Johnson
Mar 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Mekontso-DessapD Loisance
Feb 12, 2002·European Journal of Internal Medicine·D TalonJ L. Dupond
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Jean Chastre, Jean-Yves Fagon
Apr 18, 2002·Antimicrobial Agents and Chemotherapy·John E ConteElisabeth Zurlinden
May 17, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dennis L StevensBarry Hafkin
Dec 20, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara E CosgroveYehuda Carmeli
Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John J EngemannKeith S Kaye
Apr 4, 2003·International Journal of Antimicrobial Agents·UNKNOWN Members of the SFM Antibiogram Committee
Nov 20, 2003·JAMA : the Journal of the American Medical Association·Jean ChastreUNKNOWN PneumA Trial Group
Mar 5, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alain CombesClaude Gibert
Jul 10, 2004·American Journal of Respiratory and Critical Care Medicine·Alain CombesUNKNOWN PNEUMA Trial Group

❮ Previous
Next ❯

Citations

Jan 25, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C PeñaJ Ariza
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-Ralph ZaharUNKNOWN Outcomerea Study Group
Apr 6, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rodrigo Pires dos SantosFlavio Danni Fuchs
Jul 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marin H KollefJohn Segreti
Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin E Stryjewski, G Ralph Corey
Jan 6, 2007·Critical Care Medicine·Marc LeoneClaude Martin
Apr 9, 2005·Current Opinion in Pulmonary Medicine·Michael Jan Shaw
Jan 2, 2007·Current Opinion in Critical Care·Emili DiazJordi Rello
Aug 17, 2011·Current Opinion in Critical Care·Jean-François TimsitSylvie Chevret
Jul 11, 2009·The Journal of Trauma·Erika L RangelJoseph S Solomkin
Nov 19, 2008·Infection and Immunity·Ann CraigSamithamby Jeyaseelan
Mar 9, 2005·American Journal of Respiratory and Critical Care Medicine·Derek AngusEdward Abraham
Jul 1, 2006·Critical Care : the Official Journal of the Critical Care Forum·Andrew F ShorrMarin H Kollef
Aug 29, 2006·Critical Care : the Official Journal of the Critical Care Forum·Jean-François Timsit
Nov 19, 2008·Critical Care : the Official Journal of the Critical Care Forum·Pieter O DepuydtDominique D Benoit
Jan 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine LiuUNKNOWN Infectious Diseases Society of America
Sep 25, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ke-Yuan ChenMing-Hsun Lee
Jan 26, 2010·Medicina intensiva·P M OlaecheaP Luque
Oct 3, 2007·Mayo Clinic Proceedings·Evelyn E HillWilly E Peetermans
May 4, 2007·International Journal of Antimicrobial Agents·Anna M Ferrara
Jun 28, 2007·Pharmacotherapy·Thomas P Lodise, Peggy S McKinnon
Feb 10, 2006·Pharmacotherapy·Scott T MicekMarin H Kollef
May 16, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·I BoyadjievC Martin
Nov 14, 2015·Intensive Care Medicine·François BarbierSaad Nseir
Apr 26, 2006·Expert Opinion on Pharmacotherapy·Liangsu Wang, John F Barrett
Jun 15, 2005·Expert Opinion on Pharmacotherapy·C Andrew DeRykeDavid P Nicolau
Feb 28, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Simone ShurlandMary-Claire Roghmann
Mar 27, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·P GastmeierH Rüden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jean-Ralph ZaharOUTCOMEREA Study Group
American Journal of Respiratory and Critical Care Medicine
J Chastre, Jean-Yves Fagon
American Journal of Respiratory and Critical Care Medicine
American Thoracic Society, Infectious Diseases Society of America
American Journal of Respiratory and Critical Care Medicine
J L TrouilletC Gibert
© 2022 Meta ULC. All rights reserved