Impact of metoprolol treatment on cardiac function and exercise tolerance in heart failure patients with neuropsychiatric disorders

Current Medical Research and Opinion
Jingjing HuangYong Meng

Abstract

To investigate the impact of neuropsychiatric disorders on the effect of metoprolol on cardiac and motor function in chronic heart failure (CHF) patients. From February 2013 to April 2016, CHF patients with clinical mental disorders received metoprolol (23.75 or 47.5 mg, once daily, orally) at the Second Affiliated Hospital of Kunming Medical University. Mental status was confirmed by means of the Hospital Anxiety and Depression Scale (HADS) and the Copenhagen Burnout Inventory (CBI) scale. Cardiac function parameters such as systolic blood pressure (SBP), ejection fraction (EF) and cardiac index (CI) as well as motor function including the 6 meter walk test (6MWT) and the Veteran's Specific Activity Questionnaire (VSAQ) were assessed as primary outcomes of the study. A total of 154 patients (median age, 66.39 years; men, n = 101) were allocated into eight groups based on their mental status. There were no significant differences in heart rate (HR) or SBP control achieved by metoprolol in any groups compared with the control (patients with normal mental status). Furthermore, biphasic ejection fraction (EF) changes were observed in all the groups with a decrease in the first month and increase from the sixth month. However, this...Continue Reading

References

Jan 1, 1985·European Journal of Clinical Pharmacology·W P Koella
Oct 1, 1987·International Journal of Cardiology·A AppelsP Mulder
Jan 1, 1993·Cardiology·F Waagstein
Mar 5, 2002·Archives of Internal Medicine·Kenneth M A MacMahon, Gregory Y H Lip
Jun 15, 2005·Psychosomatic Medicine·Robert M CarneyRichard C Veith
Aug 18, 2005·Journal of Cardiac Failure·Varda KonstamMarla J De Jong
Sep 7, 2005·European Heart Journal·Joost P van MelleUNKNOWN MIND-IT investigators
Dec 13, 2006·Journal of the American College of Cardiology·Peter de JongeJohan Ormel
Sep 25, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Evelyne EggerRoland von Känel
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Johannes C EhrenthalHenning Schauenburg
May 28, 2010·Neuropsychiatric Disease and Treatment·Jeff C HuffmanJames L Januzzi
Feb 18, 2012·BMC Systems Biology·Naveed Aslam, Harel Z Shouval
Mar 20, 2012·Journal of the Neurological Sciences·Zoltán BajkóLászló Csiba
Jun 14, 2012·Journal of Psychosomatic Research·Elisabetta PatronDaniela Palomba
Dec 21, 2013·Journal of Substance Abuse Treatment·Jessica L MuilenburgLillian T Eby

❮ Previous
Next ❯

Citations

Mar 11, 2020·Behavioural and Cognitive Psychotherapy·Arjan C VidelerMachteld A Ouwens
Apr 14, 2018·Zebrafish·Xiao-Yu ZhuChun-Qi Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.