Impact of modified radical neck dissection on biochemical cure in medullary thyroid carcinomas

Surgery
T WeberE Klar

Abstract

This study evaluated the outcome of total thyroidectomy and modified radical neck dissection in primary treatment of patients with medullary thyroid carcinoma (MTC). Thirty-six patients with sporadic (n = 16) and hereditary (n = 20) MTC underwent thyroidectomy and systematic central and lateral lymph node dissection (unilateral, 23; bilateral, 13) between 1994 and 2000. Postoperative serum calcitonin levels were correlated with immediate or delayed surgery, tumor categories, and lymph node metastases. Sixteen of 36 (44%) patients with clinically evident MTC treated with central and lateral neck dissection exhibited normal basal and stimulated calcitonin levels at a median follow-up of 3.7 years. Lymph node involvement was detected in 75% of these patients and correlated with the TNM stages. Biochemical cure was achieved according to the T categories in 83% of the patients in stage T1, 42% in stage T2, and none of the patients in stage T4 (P = .011). Basal and stimulated calcitonin levels were found to be normal in 89% of the patients without lymph node involvement and in 30% of the patients with lymph node metastases (P = .005). Screening for MTC and primary treatment with total thyroidectomy and modified radical neck dissectio...Continue Reading

References

Jul 1, 1995·Journal of Surgical Oncology·L A MarzanoL Zarrilli
Apr 1, 1995·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H J BuhrC Herfarth
Jul 1, 1993·Human Molecular Genetics·H Donis-KellerS A Wells
Jun 1, 1997·Annals of Surgery·J F MoleyM K DeBenedetti
Dec 3, 1996·Journal of Public Health Management and Practice : JPHMP·A WojciakS Becker
Nov 24, 1999·Annals of Surgery·J B FlemingD B Evans

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Citations

Mar 5, 2013·Langenbeck's Archives of Surgery·Henning DralleUNKNOWN German Societies of General and Visceral Surgery; Endocrinology; Nuclear Medicine; Pathology; Radiooncology; Oncological Hem
Jun 3, 2008·Surgery Today·Marcos R TavaresAlberto Ferraz
Aug 29, 2003·Current Treatment Options in Oncology·Jeffrey F Moley
May 24, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A Machens, H Dralle
Jun 1, 2005·Journal of the American College of Surgeons·Electron KebebewJocelyn Grunwell
Jul 7, 2007·Thyroid : Official Journal of the American Thyroid Association·Simona Grozinsky-GlasbergMordechai Lapidot
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
Nov 4, 2010·Current Opinion in Oncology·Leslie S WuJulie A Sosa
Oct 2, 2012·Annals of Surgery·Andreas Machens, Henning Dralle
Dec 21, 2004·Journal of Internal Medicine·A MachensH Dralle
Jul 3, 2008·Annals of Surgical Oncology·Maya D LeggettSteve R Martinez
Apr 12, 2007·World Journal of Surgery·Jeffrey F Moley, Elizabeth A Fialkowski
Aug 1, 2007·World Journal of Surgery·Andreas MachensHenning Dralle
Mar 26, 2008·Pediatric Hematology and Oncology·Soumen Khatua, Laura L Bilodeau
Jun 9, 2007·Expert Review of Anticancer Therapy·Gianlorenzo DionigiLuigi Bartalena
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Theresia WeberMagnus von Knebel Doeberitz Mv
Sep 3, 2011·Journal of Visceral Surgery·S NoulletF Menegaux
Aug 3, 2006·Surgical Oncology Clinics of North America·Y Nancy YouJeffrey F Moley
May 30, 2009·International Journal of Cancer. Journal International Du Cancer·Daniel BuergyHeike Allgayer
Feb 27, 2008·The British Journal of Surgery·A MachensH Dralle
Jul 22, 2010·Journal of Surgical Oncology·Steve R MartinezPhilip D Schneider
Aug 7, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E MiralliéJ F Henry
May 26, 2004·Clinics in Laboratory Medicine·Nicole Massoll, Ernest L Mazzaferri
Nov 5, 2014·Annals of Surgical Oncology·Allen S HoIan Ganly
Apr 17, 2016·Irish Journal of Medical Science·P LennonJ P O' Neill
Mar 27, 2015·Thyroid : Official Journal of the American Thyroid Association·Samuel A WellsUNKNOWN American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Dec 4, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A Machens, H Dralle
Oct 6, 2010·Journal of Pediatric Surgery·Mehul V RavalMarleta Reynolds
Oct 27, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Aurélien ArchierDavid Taïeb
Oct 23, 2014·Thyroid : Official Journal of the American Thyroid Association·Susan C LindseyR Michael Tuttle

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