Impact of mRNA-Assessed Molecular Subtype Conversion, Intact and Apoptotic Circulating Tumor Cells on Survival of Metastatic Breast Cancer Patients: Proof of Principle

Diagnostics
Stefan StefanovicMarkus Wallwiener

Abstract

Breast cancers (BC) can mutate, allowing metastatic tumors (MT) to sometimes differ to primary tumors (PT) in gene expression. Despite contemporary metastatic breast cancer (MBC) therapy, subtype conversion seems prognostically disadvantageous. We strived to determine the influence of mRNA-assessed intrinsic subtype stability comparing PT and MT biopsies and circulating tumor cell (CTC)-based liquid biopsies on progression free survival (PFS) and overall survival (OS). Additional analyzed prognostic factors were PT subtype, MT subtype and hormone receptor loss. Kaplan-Meier curves and the log rank tests were used to compare PFSs and OSs. The proportions of luminal B and triple negative subtype MTs were increased compared to those observed in PTs. Fifteen patients were found to have tumors that underwent intrinsic subtype conversion and their OS was significantly decreased (p = 0.038). No such difference was observed when it comes to PFS. The majority of these tumors switched to a more aggressive intrinsic subtype. No significant differences in PFSs or OSs were observed between subtype converters with triple negative PTs compared to those with luminal subtype PTs. The same is true of subtype stable patients. Total CTC, iCTC and ...Continue Reading

References

Aug 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P A GreenbergA U Buzdar
Aug 30, 2000·Nature·C M PerouD Botstein
Apr 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sherene LoiChristos Sotiriou
Jan 29, 2008·Breast Cancer : the Journal of the Japanese Breast Cancer Society·A Rab RazzakEric P Winer
Jul 15, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C LiedtkeA M Gonzalez-Angulo
Apr 22, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine RiethdorfKlaus Pantel
Sep 25, 2010·Breast Cancer Research : BCR·Laurien D C HoefnagelPaul J van Diest
Nov 10, 2010·Breast Cancer Research : BCR·Alastair M ThompsonUNKNOWN Breast Recurrence in Tissues Study Group
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jun 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen K ChiaTorsten O Nielsen
Jun 20, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Linda Sofie LindströmJonas Bergh
Jun 20, 2013·Molecular Cancer Therapeutics·Galatea KallergiSofia Agelaki
May 26, 2016·Breast Cancer Research and Treatment·Ralph M WirtzHeikki Joensuu
Jul 11, 2016·The Breast : Official Journal of the European Society of Mastology·Luisa CarbogninEmilio Bria
Aug 25, 2016·The New England Journal of Medicine·Fatima CardosoUNKNOWN MINDACT Investigators
May 16, 2018·Cancer Treatment Reviews·Juan Miguel CejalvoAleix Prat
May 6, 2019·Oncology·Uwe GüthSeraina Margaretha Schmid

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Methods Mentioned

BETA
biopsy
biopsies
fluorescence-based microscopy

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