Impact of multiple blastocyst biopsy and vitrification-warming procedures on pregnancy outcomes

Fertility and Sterility
Cara K BradleyS J McArthur

Abstract

To assess the impact of multiple blastocyst biopsy and vitrification-warming procedures on clinical outcomes. Retrospective study. Private fertility clinic. Preimplantation genetic diagnosis (PGD) patients undergoing comprehensive chromosome screening, including monogenic disorder and chromosome rearrangement cases. Warming and transfer of euploid blastocysts biopsied and vitrified-warmed once (group 1 [G1, control]; n = 2,130), biopsied once but vitrified-warmed twice (group 2 [G2]; n = 34), or biopsied and vitrified-warmed twice (group 3 [G3]; n = 29). Thaw (for transfer) survival rate and clinical pregnancy rate (CPR). The thaw survival rates were 98.4% for G1, 97.3% for G2, and 93.3% for G3, with once biopsied and vitrified-warmed embryos being significantly higher than twice biopsied and vitrified-warmed embryos (G1 vs. G3; P=.032). There was a slight reduction in CPR with an additional vitrification-warming (G1 54.3% vs. G2 47.1%) and larger reduction with an additional embryo biopsy (G2 47.1% vs. G3 31.0%), but neither difference was statistically significant. However, the combined effect of both additional biopsy and vitrification-warming resulted in a significantly reduced CPR (G1 54.3% vs. G3 31.0%; P=.013). This stud...Continue Reading

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Citations

Sep 6, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Monica ParriegoAnna Veiga
Nov 13, 2018·Human Reproduction·Andrea R VictorManuel Viotti
Nov 8, 2018·Journal of Assisted Reproduction and Genetics·Shira PrinerTalia Eldar-Geva
Feb 1, 2021·Reproductive Biomedicine Online·Ashley AlukoDenny Sakkas
Aug 27, 2021·Frontiers in Cell and Developmental Biology·Li ChenBing Yao

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