Impact of Multivalence and Self-Assembly in the Design of Polymeric Antimicrobial Peptide Mimics.

ACS Applied Materials & Interfaces
Sophie LaroqueMatthias Hartlieb

Abstract

Antimicrobial resistance is an increasingly serious challenge for public health and could result in dramatic negative consequences for the health care sector during the next decades. To solve this problem, antibacterial materials that are unsusceptible toward the development of bacterial resistance are a promising branch of research. In this work, a new type of polymeric antimicrobial peptide mimic featuring a bottlebrush architecture is developed, using a combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and ring-opening metathesis polymerization (ROMP). This approach enables multivalent presentation of antimicrobial subunits resulting in improved bioactivity and an increased hemocompatibility, boosting the selectivity of these materials for bacterial cells. Direct probing of membrane integrity of treated bacteria revealed highly potent membrane disruption caused by bottlebrush copolymers. Multivalent bottlebrush copolymers clearly outperformed their linear equivalents regarding bioactivity and selectivity. The effect of segmentation of cationic and hydrophobic subunits within bottle brushes was probed using heterograft copolymers. These materials were found to self-assemble under physiologi...Continue Reading

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Citations

Dec 2, 2020·Emerging Topics in Life Sciences·Ioanna Mela, Clemens F Kaminski
Feb 23, 2021·ACS Pharmacology & Translational Science·Bhuvaneshwari BalasubramaniamRaju Kumar Gupta
Nov 24, 2020·Biomacromolecules·Shuyue ZhaoAnjie Dong
Aug 29, 2021·Angewandte Chemie·Peter R JudzewitschCyrille Boyer
Oct 7, 2021·Advanced Materials·Kenward JungCyrille Boyer

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