Impact of mycophenolic acid on the functionality of human polymorphonuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus.

Antimicrobial Agents and Chemotherapy
Markus MezgerJuergen Loeffler

Abstract

Mycophenolic acid (MPA) is used clinically to prevent graft rejection but may increase the risk of fungal infection. We observed that MPA enhanced the Aspergillus fumigatus-induced oxidative burst of polymorphonuclear neutrophils, but without a corresponding increase in fungal killing. Furthermore, MPA inhibited the proinflammatory cytokine response and maturation of dendritic cells.

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Citations

Dec 18, 2010·Future Microbiology·Louis Y A ChaiMihai G Netea
Mar 19, 2015·Virulence·Seána DugganOliver Kurzai
Jun 9, 2017·Microorganisms·Jessica L Chitty, James A Fraser
Jun 1, 2013·Probiotics and Antimicrobial Proteins·Jennifer K MillerDouglas S Watson
Jul 13, 2018·Frontiers in Pharmacology·Lisa M FleischerGregory M Miller
Jun 8, 2018·Frontiers in Medicine·Andrzej GórskiGrzegorz Węgrzyn
Aug 18, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew B Roberts, Jay A Fishman

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