Impact of Nasopharyngeal FilmArray Respiratory Panel Results on Antimicrobial Decisions in Hospitalized Patients

Canadian Respiratory Journal : Journal of the Canadian Thoracic Society
Kenneth K SakataHolenarasipur R Vikram

Abstract

To determine whether results of the nasopharyngeal FilmArray respiratory panel (NP-FARP) influenced antibiotic decisions. We reviewed the medical records of nonintensive care unit (ICU) inpatients that had an NP-FARP performed at our institution between June 2013 and June 2014. The inpatient records were reviewed 48 hours after the NP-FARP for the following data: demographic information; NP-FARP, serum procalcitonin, and methicillin-resistant Staphylococcus aureus nasal swab (MRSA NS) results; antibiotics prior and post-48 hours of the NP-FARP result; and the current immunosuppression status. Clinical outcome data were not obtained. Patients were categorized into those who had a positive (+) or a negative (-) NP-FARP. We further subdivided these two categories into groups A, B, and C based on the antibiotic modifications 48 hours after their NP-FARP result. Group A included patients who were never initiated on antimicrobial therapy. Patients whose antibiotics were discontinued or deescalated were placed in group B. Patients with antibiotic escalation or continuation without change constituted group C. We compared and analyzed groups A, B, and C in the (+) and (-) NP-FARP cohorts. A total of 545 patients were included. There wer...Continue Reading

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Citations

Aug 26, 2020·Thorax·Matthew J MartinTim W Harrison
Feb 8, 2020·Current Infectious Disease Reports·Erin H Graf, Preeti Pancholi
Dec 30, 2020·BMJ Open Respiratory Research·Mohammed A AlmeshariElizabeth Sapey
Oct 31, 2020·Clinics in Laboratory Medicine·Jennifer Dien Bard, Erin McElvania

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Methods Mentioned

BETA
bronchoalveolar lavage
PCR

Software Mentioned

SAS
R

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.