Impact of natalizumab on cognitive performances and fatigue in relapsing multiple sclerosis: a prospective, open-label, two years observational study.

PloS One
P IaffaldanoM Trojano

Abstract

Natalizumab reduces the relapse rate and magnetic resonance imaging activity in patients with Relapsing-Remitting Multiple Sclerosis (RRMS). So far the influence of natalizumab on cognitive functions and fatigue in MS remains uncertain. The aim of this prospective, open-label, observational study was to evaluate the possible effects of natalizumab on cognition and fatigue measures in RRMS patients treated for up to two years. Cognitive performances were examined by the Rao's Brief Repeatable Battery (BRB), the Stroop test (ST) and the Cognitive Impairment Index (CII), every 12 months. Patients who failed in at least 3 tests of the BRB and the ST were classified as cognitively impaired (CI). Fatigue Severity Scale (FSS) was administered every 12 months to assess patient's self-reported fatigue. One hundred and 53 patients completed 1 and 2 year-natalizumab treatment, respectively. After 1 year of treatment the percentage of CI patients decreased from 29% (29/100) at baseline to 19% (19/100) (p = 0.031) and the mean baseline values of CII (13.52±6.85) and FSS (4.01±1.63) scores were significantly reduced (10.48±7.12, p<0.0001 and 3.61±1.56, p = 0.008). These significant effects were confirmed in the subgroup of patients treated u...Continue Reading

References

Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·B F JohnsonJ Johnson
Aug 1, 1989·Journal of Clinical and Experimental Neuropsychology·S M RaoG J Leo
Oct 1, 1989·Journal of Clinical and Experimental Neuropsychology·S M RaoP St Aubin-Faubert
Apr 6, 1999·Archives of Neurology·A WeinsteinS I Schwid
Sep 11, 2002·Neurology·J A CohenUNKNOWN IMPACT Investigators
Jun 20, 2003·Multiple Sclerosis : Clinical and Laboratory Research·Rohit Bakshi
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Jun 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·L M MetzD McGowan
Oct 13, 2005·Statistics in Medicine·Heather J WhitakerPatrick Musonda
Mar 3, 2006·The New England Journal of Medicine·Chris H PolmanUNKNOWN AFFIRM Investigators
Mar 3, 2006·The New England Journal of Medicine·Richard A RudickUNKNOWN SENTINEL Investigators
Apr 29, 2006·Journal of the Neurological Sciences·Maria Pia AmatoEmilio Portaccio
Mar 3, 2007·Journal of the Neurological Sciences·Steven R SchwidUNKNOWN Copaxone Study Group
Apr 21, 2007·Annals of Neurology·Maria TrojanoMaria Pia Amato
Aug 19, 2007·Annals of Neurology·Richard A RudickUNKNOWN AFFIRM and SENTINEL Investigators
Nov 15, 2008·Lancet Neurology·Nancy D Chiaravalloti, John DeLuca
Feb 3, 2009·Multiple Sclerosis : Clinical and Laboratory Research·E PatrickUNKNOWN New York State MS Consortium
Feb 18, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M KhademiT Olsson
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diego CentonzeGianvito Martino
Jun 30, 2009·Journal of the Neurological Sciences·Norman PutzkiHans Christoph Diener
Jul 4, 2009·Journal of the International Neuropsychological Society : JINS·James F SumowskiJohn Deluca
Aug 12, 2009·Journal of Neural Transmission·Ruth Arnon, Rina Aharoni
Oct 23, 2009·Annals of Neurology·M TrojanoUNKNOWN Italian Multiple Sclerosis Database Network (MSDN) Group
Dec 17, 2009·Multiple Sclerosis : Clinical and Laboratory Research·J MellergårdC Dahle
Mar 9, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Emilio PortaccioUNKNOWN TuSCIMS Study Group
Jun 11, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·F MattioliR Capra
Jun 11, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·F RinaldiP Gallo
Jun 18, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Fredrik PiehlT Olsson
Jul 17, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G MandolesiDiego Centonze
Sep 28, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Flavia MattioliR Capra
Feb 1, 2011·Annals of Neurology·Martin GunnarssonJan Lycke
Jul 22, 2015·Multiple Sclerosis and Related Disorders·Juan Manuel RacostaMarcelo Kremenchutzky

❮ Previous
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Citations

May 1, 2013·Journal of the Neurological Sciences·R G ViterboM Trojano
Jul 26, 2014·International Journal of MS Care·John N RatchfordKathleen Costello
Jul 28, 2015·Disability and Rehabilitation·Alberto RaggiMichelle Willems
Nov 29, 2015·Neurologic Clinics·Abdorreza Naser MoghadasiMohammad Ali Sahraian
Dec 15, 2015·International Journal of Alzheimer's Disease·Mark E McCaulley, Kira A Grush
Oct 2, 2012·Clinical Neurology and Neurosurgery·Murat YildizStefan Borgwardt
Mar 12, 2016·AJNR. American Journal of Neuroradiology·O T WiebengaJ J G Geurts
Aug 24, 2016·International Journal of MS Care·Richard A SaterPamela Sater
Sep 22, 2015·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Anne WickströmAnders Svenningsson
Feb 15, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Pietro IaffaldanoMaria Trojano
Mar 11, 2015·Frontiers in Neurology·Iris-Katharina PennerUNKNOWN TYNERGY trial investigators
Sep 14, 2017·Acta Neurologica Scandinavica·I RorsmanP C Nilsson
May 24, 2014·Journal of Central Nervous System Disease·Robert HoepnerAndrew Chan
Dec 18, 2013·The Cochrane Database of Systematic Reviews·Dian HeHongyu Zhou
Sep 27, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Gauruv BoseMark S Freedman
Mar 5, 2019·Expert Review of Neurotherapeutics·Maria Pia AmatoAngelo Bellinvia
Oct 14, 2017·Nature Reviews. Neurology·Iris-Katharina Penner, Friedemann Paul
Aug 9, 2017·Reviews in the Neurosciences·Tomasz Grzegorski, Jacek Losy
Feb 6, 2020·Neurology. Neuroimmunology and Neuroinflammation·Gerd Haga BringelandSonia Gavasso
Jun 5, 2020·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Christos BakirtzisNikolaos Grigoriadis
Sep 2, 2016·Acta Neurologica Scandinavica·M MückschelT Ziemssen
Apr 24, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mariana BrancoMaria Pia Amato
Oct 23, 2018·Current Treatment Options in Neurology·Arseny A SokolovRiley Bove
May 18, 2019·Journal of Neural Transmission·Klara NovotnaJana Lizrova Preiningerova
Oct 18, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Elena Lozano-SotoJavier J González-Rosa
Dec 11, 2020·Multiple Sclerosis and Related Disorders·Gustavo M de AlmeidaLineu C Werneck
Nov 19, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ruggero CapraUNKNOWN WANT Investigators
Aug 26, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Dawn W LangdonLudwig Kappos

❮ Previous
Next ❯

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