Impact of natural polymorphisms of HIV-1 non-group M on genotypic susceptibility to the attachment inhibitor fostemsavir

The Journal of Antimicrobial Chemotherapy
E Alessandri-GradtJ C Plantier

Abstract

Fostemsavir belongs to the new class of attachment inhibitors (AIs); it inhibits the entry of HIV into CD4+ T-lymphocytes by blocking conformational changes in gp120. This is a promising AI, but previous phenotypic data showed that genetically divergent HIV-1 group O could present natural resistance to this drug. These data were obtained from only two strains, which are not representative of the high intra-group genetic diversity. Moreover, no data are available concerning the other divergent HIV-1 groups (N and P). To further investigate the natural genotypic susceptibility of HIV-1 groups O, N and P (HIV-1 non-M) to fostemsavir, using a large set of sequences. The frequency of eight substitutions associated with decreased susceptibility to fostemsavir (L116P, A204D, S375M/H, M426L, M434I, M475I and V506M), was investigated in 111 gp120 sequences from groups O (n = 100), N (n = 9) and P (n = 2). All HIV-1 group N sequences harboured the three substitutions S375M, M426L and M434I, whereas only 1% and 10% of HIV-1 group O sequences harboured the S375H + M426L and S375H + M434I patterns, respectively. The main genetic profile of HIV-1 groups P and O combined S375H with two atypical substitutions (M426S and M434L). Five group O se...Continue Reading

References

Nov 17, 2010·Antimicrobial Agents and Chemotherapy·Nannan ZhouPin-Fang Lin
Jan 15, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Agnès DepatureauxJean-Christophe Plantier
Jul 5, 2013·Clinical Microbiology Reviews·Thomas MourezJean-Christophe Plantier
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Oct 2, 2014·The Journal of Antimicrobial Chemotherapy·Djeneba B FofanaCathia Soulié
Aug 5, 2015·PLoS Pathogens·Marie LeozJean-Christophe Plantier
Sep 2, 2017·The Journal of Antimicrobial Chemotherapy·E Alessandri-GradtJ C Plantier
Dec 6, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Max LatailladeUNKNOWN AI438011 study team

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Citations

Mar 12, 2020·The Journal of Antimicrobial Chemotherapy·Yagai BoubaMaria Mercedes Santoro
Jun 26, 2020·MMW Fortschritte der Medizin·Eva Wolf, Sebastian Noe
May 29, 2020·The Journal of Antimicrobial Chemotherapy·Francesco SaladiniAntonella Castagna
Sep 23, 2020·Annual Review of Pharmacology and Toxicology·Zaikuan J YuNamandjé N Bumpus
Feb 7, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Elias B Chahine

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